mechanism 1,315 words KG: ent-gene-dab15615
Contents

Sigma-1 Receptor (SIGMAR1) Signaling in Parkinson's Disease

🔬 Protein Info
Gene Symbolent-gene-dab15615
Subcellular LocalizationER-mitochondria contact sites (mitochondria-associated membranes, MAMs) that regulates calcium homeostasis, mitochondria
NeurosteroidsPregnenolone, DHEA
SphingolipidsCeramide
PRE-084Selective sigma-1 agonist
SA-4503 (Cutamesine)Agonist with neuroprotective effects
DextromethorphanFDA-approved cough suppressant with sigma-1 agonist activity
KG Connections2 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Related Hypotheses (55)

LRP1-Dependent Tau Uptake Disruption
Score: 0.60
Brain Insulin Resistance with Glucose Transporter Dysfunctio
Score: 0.60
Netrin-1 Gradient Restoration
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TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
Astroglial Gap Junction Coordination via Connexin-43 Phospho
Score: 0.57
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56
Blood-Brain Barrier SPM Shuttle System
Score: 0.53
Gut Barrier Permeability-α-Synuclein Axis Modulation
Score: 0.53
PINK1/Parkin-Independent Mitophagy Bypass for Enhanced Donor
Score: 0.53
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48
Optogenetic Control of Mitochondrial Transfer Networks
Score: 0.48
Microbiome-Derived Tryptophan Metabolite Neuroprotection
Score: 0.43
Gap Junction Hemichannel Modulation for Controlled Mitochond
Score: 0.36
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.88
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
← Prevpg 3/3

Related Analyses (30)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
TREM2 agonism vs antagonism in DAM microglia
neurodegeneration · completed
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived

Related Experiments (30)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40
TREM2 Agonist Therapy for Parkinson's Disease — Experimental
validation · proposed · Score: 0.45
AAV Serotype Comparison for LRRK2 Knockdown in PD
validation · proposed · Score: 0.40
Alpha-Synuclein SAA Kinetics Study — Biological Staging Back
clinical · proposed · Score: 0.40
Alpha-Synuclein Aggregation Triggers — Sporadic PD Initiatio
clinical · proposed · Score: 0.40

Knowledge Graph (2 edges)

ent-gene-dab15615 data_in benchmark_ot_ad_answer_key:SIGMAR1
benchmark_ot_ad_answer_key:SIGMAR1 data_in ent-gene-dab15615

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