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mechanism 1,628 words KG: ent-gene-28e2cb01 2026-03-28
kind:mechanismsection:mechanismsstate:published
Contents

TREM2 Inflammatory Cytokine Regulation

🔬 Protein Info
Gene Symbolent-gene-28e2cb01
Direct SYK-IKK activationSYK phosphorylates IKK complex
PI3K/AKT effectsAKT promotes IKK activity
ROS-dependent activationTREM2 can increase ROS production via NADPH oxidase
KG Connections5 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

TREM2-Dependent Astrocyte-Microglia Cross-talk in Neurodegen
Score: 0.64TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegene
Score: 0.61TREM2-Mediated Astrocyte-Microglia Crosstalk in Neurodegener
Score: 0.61TREM2-CSF1R Cross-Talk in Microglial Metabolic Reprogramming
Score: 0.59TREM2-SIRT1 Metabolic Senescence Circuit in Microglial Aging
Score: 0.59

Related Analyses (30)

Immune atlas neuroinflammation analysis in neurodegeneration
Neuroinflammation · completedNeuroinflammation and microglial priming in early Alzheimer'
neurodegeneration · archivedNeuroinflammation and microglial priming in early AD
neurodegeneration · completedTREM2 Therapeutic Strategy Post-INVOKE-2
neurodegeneration · archivedMechanistic validation of SEA-AD differential expression hyp
neurodegeneration · failed

Related Experiments (30)

TREM2 KO amyloid pathology study
validation · completed · Score: 0.75TREM2 KO amyloid pathology study
validation · completed · Score: 0.75TREM2 KO amyloid pathology study
validation · in_progress · Score: 0.75TREM2 KO amyloid pathology study
validation · completed · Score: 0.75TREM2 KO amyloid pathology study
validation · completed · Score: 0.75

See Also (7)

TREM2 Gene-Mechanism-Therapy Chain — From Genetic Risk
mechanism · Pages share 3 hypothesesTREM2 in Frontotemporal Dementia
mechanism · Pages share 3 hypothesesTREM2 in Amyotrophic Lateral Sclerosis
mechanism · Pages share 3 hypothesesTREM2 Gene
gene · Pages share 3 hypothesesal002-trem2-agonist-alzheimers
clinical_trial · Pages share 3 hypotheses

Knowledge Graph (5 edges)

ent-gene-28e2cb01 expressed_in microglia
ent-gene-28e2cb01 data_in ad_genetic_risk_loci:TREM2
ent-gene-28e2cb01 data_in benchmark_ot_ad_answer_key:TREM2
ad_genetic_risk_loci:TREM2 data_in ent-gene-28e2cb01
benchmark_ot_ad_answer_key:TREM2 data_in ent-gene-28e2cb01
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