| Gene Symbol | ent-gene-a35fbac2 |
| MST1/2 (hippo) | Mammalian STE20-like kinases 1 and 2, the upstream kinases[@mst] |
| SAV1 (Salvador) | Scaffold protein that promotes MST1/2 activation |
| LATS1/2 (Warts) | Large tumor suppressor kinases that phosphorylate YAP/TAZ[@lats] |
| MOB1 (Mats) | Co-substrate for LATS1/2 |
| YAP (Yes-associated protein) | Transcriptional coactivator encoded by the **YAP1** gene[@yap] |
| TAZ (WWTR1) | Transcriptional coactivator with PDZ-binding motif, encoded by **WWTR1**[@wwtr] |
| TEAD1-4 | Primary transcription factor partners for YAP/TAZ[@tead] |
| Mechanical stress | Cell stiffness, substrate rigidity, and stretch |
| Cell polarity | Par complex and Crumbs complex |
| GPCR signaling | Gα12/13 and Rho GTPases |
| Energy status | AMPK phosphorylates YAP[@ampkyap] |
| DNA damage | ATM/ATR kinases |
| YAP activators | Small molecules that promote YAP nuclear localization |
| TEAD inhibitors | Disrupt YAP-TEAD transcriptional activity (in development) |
| Mechanical stimulation | Vibrational therapy and physical exercise may activate Hippo signaling |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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