protein 591 words KG: APH1A 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

APH1A Protein

🔬 Protein Info
Gene SymbolAPH1A
AliasesPage for APH1A Gene, Page for APH1A Protein
Chromosome1p36.22
Protein FamilyAph-1 family (gamma-secretase)
Function### Gamma-Secretase Complex Component
Primary ExpressionBrain (cerebral cortex, hippocampus, cerebellum), Heart, Liver, Kidney, Pancreas
Subcellular LocalizationEndoplasmic reticulum, Golgi, plasma membrane
Molecular Weight28.5 kDa
Amino Acids257 aa
Pathwaysnotch, Notch signaling
UniProt IDQ9Y6X0
Ensembl IDENSG00000144024
GeneCardsAPH1A
Human Protein AtlasAPH1A
Associated DiseasesAlzheimer's Disease, Familial Alzheimer's Disease
InteractionsAPH1B, PSEN1, PSEN2
KG Connections7 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (12)

Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.53

Related Analyses (6)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

Knowledge Graph (7 edges)

APH1A inhibits APH1B
APH1A inhibits PSEN1
APH1A inhibits PSEN2
APH1A data_in benchmark_ot_ad_answer_key:APH1A
APH1A provides_data_for ds-83b31ef18d49
benchmark_ot_ad_answer_key:APH1A data_in APH1A
ds-83b31ef18d49 data_in APH1A