| Gene Symbol | PSEN1 |
| Full Name | Presenilin 1 |
| Chromosome | 14q24.2 |
| Protein Type | Aspartyl protease (catalytic subunit) |
| Function | β-Secretase Cleavage: APP is first cleaved by BACE1 to generate C99 (membrane-bound C-terminal fragment) |
| Primary Expression | Neurons (high), astrocytes, many peripheral tissues |
| Molecular Weight | 27 kDa |
| Amino Acids | 467 aa |
| Pathways | Amyloid, Autophagy, Blood-Brain Barrier, Cholesterol, Dysbiosis |
| UniProt ID | P49768 |
| NCBI Gene ID | 5663 |
| Ensembl ID | ENSG00000118784 |
| OMIM | 104311 |
| GeneCards | PSEN1 |
| Human Protein Atlas | PSEN1 |
| Associated Diseases | AD, ALS, ALZHEIMER, AMI, Aging |
| Known Drugs/Compounds | RAPAMYCIN, rapamycin |
| Interactions | DAPK1, HSPG2, IL1B, APP, EIF2AK2, CD33 |
| KG Connections | 1521 knowledge graph edges |
| Databases | GeneCardsHPASTRING |