gene 790 words KG: APH1B 2026-03-22
kind:genesection:genesstate:published
Contents

APH1B Gene - Anterior Pharynx Defective 1 Homolog B

🧬 Gene Info
Gene SymbolAPH1B
Full NameAph-1 Homolog B, Gamma-Secretase Subunit
AliasesAPH-1B
Chromosome15q22.2
FunctionGamma-secretase complex subunit, cleaves APP and Notch
Subcellular Localization**Substrate Processing**: Contributes to the recognition and processing of various type I transmembrane protein substrat
Molecular Weight28.5 kDa
Amino Acids257
PathwaysGamma-secretase complex, Notch signaling, APP processing
UniProt IDQ8WW43
NCBI Gene ID83464
Ensembl IDENSG00000138613
OMIM607630
GeneCardsAPH1B
Human Protein AtlasAPH1B
Associated DiseasesAD, AMI, Als, Alzheimer, Alzheimer's disease, RA
InteractionsAPOE, IL6, SREBF1, PSEN2, A2M, DHCR24
KG Connections101 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (14)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
PARP1 Inhibition Therapy
Score: 0.58
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54

Related Analyses (6)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (10)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: interacts_with
Packard Center for ALS Research
institution · KG edge: implicated_in
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
Alzheimer Indonesia
institution · KG edge: implicated_in
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: interacts_with

Knowledge Graph (12 edges)

APH1B interacts_with APOE
APH1B interacts_with IL6
APH1B interacts_with SREBF1
APH1B interacts_with PSEN2
APH1B interacts_with A2M
APH1B interacts_with DHCR24
APH1B interacts_with HMGCR
APH1B interacts_with MAPT
APH1B interacts_with PARP1
APH1B interacts_with PEN2