protein 668 words KG: APOC1PROTEIN 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

Apolipoprotein C-I

🔬 Protein Info
Gene SymbolAPOC1PROTEIN
Full NameApolipoprotein C-I
Chromosome19.
Protein FamilyApolipoprotein family
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionvarious brain regions and cell types
Subcellular LocalizationPlasma, CSF
Molecular Weight9 kDa
UniProt IDP02654
GeneCardsAPOC1PROTEIN
Human Protein AtlasAPOC1PROTEIN
AttributeValue
Protein NameApolipoprotein C-I
GeneAPOC1
PDB ID1WRP
Associated Diseasesneurodegeneration
InteractionsAPOC2, SOAT1, ABCA2, LDLR, APOC3, APOE
KG Connections114 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (12)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
APOE Isoform Conversion Therapy
Score: 0.44
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.53

Related Analyses (7)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
APOE4 (Apolipoprotein E4)
disease · Pages share 3 hypotheses
APOE3 (Apolipoprotein E3)
disease · Pages share 3 hypotheses
APOE2 (Apolipoprotein E2)
disease · Pages share 3 hypotheses
UPenn Observational Research Repository (NCT04715399)
clinical · Pages share 3 hypotheses