Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about abca2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ABCA2 |
| Aliases | Page for ABCA2 Gene |
| Chromosome | 9q34.3 (human) |
| Protein Family | ABC transporter family, subfamily A |
| Protein Type | Transporter |
| Function | encodes a member of the ATP-binding cassette transporter family, predominantly expressed in the brain. |
| Molecular Weight | 270 kDa |
| Amino Acids | 2436 aa |
| Pathways | Cholesterol |
| UniProt ID | Q9BZC7 |
| NCBI Gene ID | 20 |
| GeneCards | ABCA2 |
| Human Protein Atlas | ABCA2 |
| Associated Diseases | Alzheimer's disease risk, Neurodegeneration |
| Interactions | APOA1, apoc1, apoc2, apoc3, LRP1, CYP46A1 |
| KG Connections | 12 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
ABCA2["ABCA2"]
ABCA2 -->|"expressed in"| Cancer["Cancer"]
ABCA2 -->|"expressed in"| Carcinoma["Carcinoma"]
ABCA2 -->|"regulates"| Alzheimer["Alzheimer"]
ABCA2 -->|"regulates"| Als["Als"]
ABCA2 -->|"regulates"| Atherosclerosis["Atherosclerosis"]
ABCA2 -->|"transports"| ALS["ALS"]
ABCD3["ABCD3"] -->|"expressed in"| ABCA2
CH25H["CH25H"] -->|"activates"| ABCA2
LRP8["LRP8"] -->|"activates"| ABCA2
APOA1["APOA1"] -->|"activates"| ABCA2
MAPT["MAPT"] -->|"regulates"| ABCA2
LRP1["LRP1"] -->|"activates"| ABCA2
LIPA["LIPA"] -->|"regulates"| ABCA2
ALZHEIMER["ALZHEIMER"] -->|"regulates"| ABCA2Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||