protein 1,392 words KG: CDC37PROTEIN 2026-03-29
kind:proteinsection:proteinstopic:alzheimerstopic:parkinsonstopic:alsstate:published
Contents

CDC37 (Cell Division Cycle 37) Protein

🔬 Protein Info
Gene SymbolCDC37
Full NameCell Division Cycle 37
Chromosome19p13.3
Protein TypeChaperone
FunctionCDC37 (Cell Division Cycle 37) is an Hsp90 co-chaperone that specifically facilitates the folding and maturation of protein kinases.
Primary Expressionmany cancers
PathwaysChaperone
UniProt IDP16234
NCBI Gene ID2881
Ensembl IDENSG00000105401
OMIM164860
GeneCardsCDC37
Human Protein AtlasCDC37
ModificationEffect
Phosphorylation (Ser/Thr)Modulates Hsp90 interaction, client release
Associated DiseasesAls, Cancer, Tumor
InteractionsPINK1, HSP90
KG Connections15 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (9)

SASP-Mediated Complement Cascade Amplification
Score: 0.70
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Senescent Cell Mitochondrial DNA Release
Score: 0.54
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42

Related Analyses (9)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (7)

Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
Proposed experiment from debate on Senolytics targeting p16/
falsification · proposed · Score: 0.40
Mechanism: Why Does Amyloid Removal Only Slow Decline 27%?
clinical · proposed · Score: 0.40
Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40
Mixed Pathology Effects on Parkinson's Disease Progression a
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in