protein 898 words KG: CLCN7PROTEIN
Contents

ClC-7 Chloride Channel

🔬 Protein Info
Gene SymbolCLCN7PROTEIN
Full NameClC-7 Chloride Channel
Chromosome3p21.31.
Protein FamilyCLC chloride channel family
Protein TypeChannel
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary ExpressionUbiquitous (brain, bone, kidney, liver)
Subcellular Localizationin late endosomes and lysosomes Citation needed
Molecular Weight~89 kDa
UniProt IDP51798
GeneCardsCLCN7PROTEIN
Human Protein AtlasCLCN7PROTEIN
BrainHigh expression in neurons, especially in hippocampus and cortex
BoneOsteoclasts highly express ClC-7 for bone resorption
KidneyProximal tubule cells
Associated Diseasesneurodegeneration
InteractionsAMPD2, GNAI3, GNPTG, WDR81
KG Connections23 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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UniProtWikipedia

Related Hypotheses (6)

Mechanosensitive Ion Channel Reprogramming
Score: 0.70
Lysosomal Calcium Channel Modulation Therapy
Score: 0.70
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.67
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (9)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived

Related Experiments (12)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40
Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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