Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ampd2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | AMPD2 |
| Full Name | Adenosine Monophosphate Deaminase 2 |
| Aliases | SPG63 |
| Chromosome | 1p13.3 |
| Protein Family | AMP deaminase family |
| Protein Type | Enzyme |
| Function | catalyzes AMP deamination to IMP |
| Primary Expression | skeletal muscle, heart, and brain |
| Molecular Weight | 85 kDa |
| Amino Acids | 771 aa |
| Pathways | mTOR, AMPK |
| UniProt ID | Q01469 |
| NCBI Gene ID | 271 |
| Ensembl ID | ENSG00000116337 |
| OMIM | 102771 |
| GeneCards | AMPD2 |
| Human Protein Atlas | AMPD2 |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
AMPD2["AMPD2"]
AMPD2 -->|"expressed in"| Cardiovascular["Cardiovascular"]
AMPD2 -->|"expressed in"| ATG5["ATG5"]
AMPD2 -->|"expressed in"| MAVS["MAVS"]
AMPD2 -->|"expressed in"| TBK1["TBK1"]
AMPD2 -->|"activates"| CLCN7["CLCN7"]
AMPD2 -->|"expressed in"| RIPK2["RIPK2"]
AMPD2 -->|"expressed in"| IFIH1["IFIH1"]
AMPD2 -->|"expressed in"| GNAI1["GNAI1"]
AKT1["AKT1"] -->|"expressed in"| AMPD2
AUTOPHAGY["AUTOPHAGY"] -->|"expressed in"| AMPD2
AKT["AKT"] -->|"expressed in"| AMPD2
GNB1["GNB1"] -->|"expressed in"| AMPD2| Target | Relation | Type | Str |
|---|---|---|---|
| Cardiovascular | expressed_in | disease | 0.65 |
| ATG5 | expressed_in | gene | 0.60 |
| MAVS | expressed_in | gene | 0.60 |
| TBK1 | expressed_in | gene | 0.60 |
| CLCN7 | activates | gene | 0.60 |
| RIPK2 | expressed_in | gene | 0.60 |
| IFIH1 | expressed_in | gene | 0.60 |
| GNAI1 | expressed_in | gene | 0.60 |
| ATG16L1 | expressed_in | gene | 0.60 |
| GNG2 | expressed_in | gene | 0.60 |
| WDR81 | activates | gene | 0.60 |
| GNPTG | activates | gene | 0.60 |
| GNAI2 | expressed_in | gene | 0.60 |
| NOD2 | expressed_in | gene | 0.60 |
| GNAS | expressed_in | gene | 0.60 |
| GNAI3 | activates | gene | 0.60 |
| Autophagy | expressed_in | pathway | 0.60 |
| Wnt | expressed_in | pathway | 0.60 |
| Akt | expressed_in | pathway | 0.60 |
| benchmark_ot_ad_answer_key:AMPD2 | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| AKT1 | expressed_in | gene | 0.60 |
| AKT | expressed_in | gene | 0.60 |
| GNB1 | expressed_in | gene | 0.60 |
| AUTOPHAGY | expressed_in | gene | 0.60 |
| benchmark_ot_ad_answer_key:AMPD2 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||