Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GNPTG: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
GNPTG is a gene implicated in neurodegeneration research. Key relationships include: expressed in, activates, implicated in. Associated with Cardiovascular. Connected to 24 entities in the SciDEX knowledge graph.
| Gene Symbol | GNPTG |
| Chromosome | 12q24.31 |
| Function | encodes a protein that functions as part of a heterodimeric complex with GNPTAB. |
| Pathways | Autophagy, Wnt, Akt |
| GeneCards | GNPTG |
| Human Protein Atlas | GNPTG |
| Step | Reaction |
| 1 | Transfer of GlcNAc-1-P to lysosomal enzyme |
| 2 | Removal of GlcNAc leaving mannose-1-P |
| Enzyme Class | Examples |
| Proteases | Cathepsins D, L |
| Lipases | Acid lipase |
| Glycosidases | β-Glucocerebrosidase |
| Sulfatases | Arylsulfatase |
| Interactor | Function |
| Associated Diseases | neurodegeneration |
| Interactions | GNAI3, AMPD2, CLCN7, WDR81 |
| KG Connections | 23 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
GNPTG["<b>GNPTG</b>"]
Cardiovascular{"Cardiovascular"}
GNPTG -->|"expressed in"| Cardiovascular
GNAI2["GNAI2"]
GNPTG -->|"expressed in"| GNAI2
NOD2["NOD2"]
GNPTG -->|"expressed in"| NOD2
GNAS["GNAS"]
GNPTG -->|"expressed in"| GNAS
GNAI3["GNAI3"]
GNPTG -->|"activates"| GNAI3
Autophagy(["Autophagy"])
GNPTG -->|"expressed in"| Autophagy
Wnt(["Wnt"])
GNPTG -->|"expressed in"| Wnt
Akt(["Akt"])
GNPTG -->|"expressed in"| Akt
neurodegeneration["neurodegeneration"]
GNPTG -->|"implicated in"| neurodegeneration
AKT1["AKT1"]
AKT1 -->|"expressed in"| GNPTG
AUTOPHAGY["AUTOPHAGY"]
AUTOPHAGY -->|"expressed in"| GNPTG
AKT["AKT"]
AKT -->|"expressed in"| GNPTG
GNB1["GNB1"]
GNB1 -->|"expressed in"| GNPTG
AMPD2["AMPD2"]
AMPD2 -->|"activates"| GNPTG
ATG5["ATG5"]
ATG5 -->|"expressed in"| GNPTG
MAVS["MAVS"]
MAVS -->|"expressed in"| GNPTG
TBK1["TBK1"]
TBK1 -->|"expressed in"| GNPTG
CLCN7["CLCN7"]
CLCN7 -->|"activates"| GNPTG
RIPK2["RIPK2"]
RIPK2 -->|"expressed in"| GNPTG
IFIH1["IFIH1"]
IFIH1 -->|"expressed in"| GNPTG
GNAI1["GNAI1"]
GNAI1 -->|"expressed in"| GNPTG
style GNPTG fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Source | Relation | Type | Str |
|---|---|---|---|
| AKT1 | expressed_in | gene | 0.60 |
| AKT | expressed_in | gene | 0.60 |
| GNB1 | expressed_in | gene | 0.60 |
| AMPD2 | activates | gene | 0.60 |
| ATG5 | expressed_in | gene | 0.60 |
| MAVS | expressed_in | gene | 0.60 |
| TBK1 | expressed_in | gene | 0.60 |
| CLCN7 | activates | gene | 0.60 |
| RIPK2 | expressed_in | gene | 0.60 |
| IFIH1 | expressed_in | gene | 0.60 |
| GNAI1 | expressed_in | gene | 0.60 |
| ATG16L1 | expressed_in | gene | 0.60 |
| GNG2 | expressed_in | gene | 0.60 |
| WDR81 | activates | gene | 0.60 |
| AUTOPHAGY | expressed_in | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||