gene

GNPTG

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GNPTG: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

23Connections
0Hypotheses
0Analyses
8Outgoing
15Incoming

Summary

GNPTG is a gene implicated in neurodegeneration research. Key relationships include: expressed in, activates, implicated in. Associated with Cardiovascular. Connected to 24 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolGNPTG
Chromosome12q24.31
Functionencodes a protein that functions as part of a heterodimeric complex with GNPTAB.
PathwaysAutophagy, Wnt, Akt
GeneCardsGNPTG
Human Protein AtlasGNPTG
StepReaction
1Transfer of GlcNAc-1-P to lysosomal enzyme
2Removal of GlcNAc leaving mannose-1-P
Enzyme ClassExamples
ProteasesCathepsins D, L
LipasesAcid lipase
Glycosidasesβ-Glucocerebrosidase
SulfatasesArylsulfatase
InteractorFunction
Associated Diseasesneurodegeneration
InteractionsGNAI3, AMPD2, CLCN7, WDR81
KG Connections23 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (9)

Knowledge base pages for this entity

Canonical Page

gnptg

gene · 1263 words

WDR81 — WD Repeat Domain 81

gene · 2168 words

GNG2 Gene

gene · 2140 words

AMPD2 — Adenosine Monophosphate Deaminase 2

gene · 1710 words

GNPTAB — N-Acetylglucosamine-1-Phosphate Transferase Alpha/Beta

gene · 1500 words

IFIH1 Gene (MDA5)

gene · 1077 words

Pathway Diagram

graph TD
    GNPTG["<b>GNPTG</b>"]
    Cardiovascular{"Cardiovascular"}
    GNPTG -->|"expressed in"| Cardiovascular
    GNAI2["GNAI2"]
    GNPTG -->|"expressed in"| GNAI2
    NOD2["NOD2"]
    GNPTG -->|"expressed in"| NOD2
    GNAS["GNAS"]
    GNPTG -->|"expressed in"| GNAS
    GNAI3["GNAI3"]
    GNPTG -->|"activates"| GNAI3
    Autophagy(["Autophagy"])
    GNPTG -->|"expressed in"| Autophagy
    Wnt(["Wnt"])
    GNPTG -->|"expressed in"| Wnt
    Akt(["Akt"])
    GNPTG -->|"expressed in"| Akt
    neurodegeneration["neurodegeneration"]
    GNPTG -->|"implicated in"| neurodegeneration
    AKT1["AKT1"]
    AKT1 -->|"expressed in"| GNPTG
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"expressed in"| GNPTG
    AKT["AKT"]
    AKT -->|"expressed in"| GNPTG
    GNB1["GNB1"]
    GNB1 -->|"expressed in"| GNPTG
    AMPD2["AMPD2"]
    AMPD2 -->|"activates"| GNPTG
    ATG5["ATG5"]
    ATG5 -->|"expressed in"| GNPTG
    MAVS["MAVS"]
    MAVS -->|"expressed in"| GNPTG
    TBK1["TBK1"]
    TBK1 -->|"expressed in"| GNPTG
    CLCN7["CLCN7"]
    CLCN7 -->|"activates"| GNPTG
    RIPK2["RIPK2"]
    RIPK2 -->|"expressed in"| GNPTG
    IFIH1["IFIH1"]
    IFIH1 -->|"expressed in"| GNPTG
    GNAI1["GNAI1"]
    GNAI1 -->|"expressed in"| GNPTG
    style GNPTG fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (8)

TargetRelationTypeStr
Cardiovascularexpressed_indisease0.65
GNAI2expressed_ingene0.60
NOD2expressed_ingene0.60
GNASexpressed_ingene0.60
GNAI3activatesgene0.60

Incoming (15)

SourceRelationTypeStr
AKT1expressed_ingene0.60
AKTexpressed_ingene0.60
GNB1expressed_ingene0.60
AMPD2activatesgene0.60
ATG5expressed_ingene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found