Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GNAI3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Comprehensive gene profile for GNAI3, a Gi/o family G protein alpha subunit involved in neuronal signaling, synaptic transmission, and neurodegenerative disease pathogenesis.
| Gene Symbol | GNAI3 |
| Full Name | G Protein Subunit Alpha I3 |
| Aliases | G Protein Alpha i3 |
| Chromosome | 1p31.3. |
| Function | Ligand binding to GPCR (e.g., dopamine D2, adenosine A1, muscarinic M2/M4) |
| Molecular Weight | 40 kDa |
| Amino Acids | 354 aa |
| UniProt ID | [P08754](https://www.uniprot.org/uniprot/P08754) |
| Ensembl ID | ENSG00000165197 |
| OMIM | 616377 |
| GeneCards | GNAI3 |
| Human Protein Atlas | GNAI3 |
| Associated Diseases | Als, Ms |
| Interactions | AKT, AKT1, GNB1, AMPD2, ATG5, MAVS |
| KG Connections | 57 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
GNAI3["<b>GNAI3</b>"]
Als{"Als"}
GNAI3 -->|"associated with"| Als
Ms{"Ms"}
GNAI3 -->|"associated with"| Ms
Cardiovascular{"Cardiovascular"}
GNAI3 -->|"expressed in"| Cardiovascular
WIPI1["WIPI1"]
GNAI3 -->|"expressed in"| WIPI1
Autophagy(["Autophagy"])
GNAI3 -->|"associated with"| Autophagy
GNAI3 -->|"interacts with"| Autophagy
Wnt(["Wnt"])
GNAI3 -->|"expressed in"| Wnt
Akt(["Akt"])
GNAI3 -->|"interacts with"| Akt
neurodegeneration["neurodegeneration"]
GNAI3 -->|"implicated in"| neurodegeneration
MIRNAS["MIRNAS"]
MIRNAS -->|"associated with"| GNAI3
C9ORF72["C9ORF72"]
C9ORF72 -->|"expressed in"| GNAI3
CD8["CD8"]
CD8 -->|"associated with"| GNAI3
LRRK2["LRRK2"]
LRRK2 -->|"expressed in"| GNAI3
IMMUNE_INFILTRATION["IMMUNE INFILTRATION"]
IMMUNE_INFILTRATION -->|"associated with"| GNAI3
MICRORNAS["MICRORNAS"]
MICRORNAS -->|"associated with"| GNAI3
AUTOPHAGY["AUTOPHAGY"]
AUTOPHAGY -->|"associated with"| GNAI3
GBA["GBA"]
GBA -->|"expressed in"| GNAI3
WDFY3["WDFY3"]
WDFY3 -->|"expressed in"| GNAI3
PIK3CB["PIK3CB"]
PIK3CB -->|"expressed in"| GNAI3
RALB["RALB"]
RALB -->|"expressed in"| GNAI3
AUTOPHAGY_RELATED_GENES["AUTOPHAGY-RELATED GENES"]
AUTOPHAGY_RELATED_GENES -->|"associated with"| GNAI3
style GNAI3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| NLGN3 | mediates | protein | 0.95 |
| AKT | activates | protein | 0.90 |
| IL6 | inhibits | entity | 0.80 |
| Als | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Cardiovascular | expressed_in | disease | 0.65 |
| Alzheimer | therapeutic_target | disease | 0.65 |
| WIPI1 | expressed_in | gene | 0.60 |
| TAU | therapeutic_target | gene | 0.60 |
| PTEN | therapeutic_target | gene | 0.60 |
| Autophagy | associated_with | pathway | 0.60 |
| Autophagy | interacts_with | pathway | 0.60 |
| Wnt | expressed_in | pathway | 0.60 |
| Akt | interacts_with | pathway | 0.60 |
| APP/PS1 | therapeutic_target | gene | 0.60 |
| MIRNAS | therapeutic_target | gene | 0.60 |
| Immune Response | therapeutic_target | pathway | 0.60 |
| Stem Cell | therapeutic_target | cell_type | 0.60 |
| Neuron | therapeutic_target | cell_type | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| GNAI2 | downregulates | gene | 0.70 |
| C9ORF72 | expressed_in | gene | 0.60 |
| CD8 | associated_with | gene | 0.60 |
| LRRK2 | expressed_in | gene | 0.60 |
| GBA | expressed_in | gene | 0.60 |
| WDFY3 | expressed_in | gene | 0.60 |
| PIK3CB | expressed_in | gene | 0.60 |
| RALB | expressed_in | gene | 0.60 |
| AKT1 | interacts_with | gene | 0.60 |
| AKT | interacts_with | gene | 0.60 |
| GNB1 | interacts_with | gene | 0.60 |
| AMPD2 | activates | gene | 0.60 |
| ATG5 | interacts_with | gene | 0.60 |
| MAVS | interacts_with | gene | 0.60 |
| TBK1 | interacts_with | gene | 0.60 |
| CLCN7 | activates | gene | 0.60 |
| RIPK2 | interacts_with | gene | 0.60 |
| IFIH1 | interacts_with | gene | 0.60 |
| GNAI1 | interacts_with | gene | 0.60 |
| ATG16L1 | interacts_with | gene | 0.60 |
| GNG2 | interacts_with | gene | 0.60 |
| WDR81 | activates | gene | 0.60 |
| GNPTG | activates | gene | 0.60 |
| GNAI2 | interacts_with | gene | 0.60 |
| NOD2 | interacts_with | gene | 0.60 |
| GNAS | interacts_with | gene | 0.60 |
| MYC | therapeutic_target | gene | 0.60 |
| AKT3 | therapeutic_target | gene | 0.60 |
| TNF | therapeutic_target | gene | 0.60 |
| MIRNAS | associated_with | gene | 0.60 |
| IMMUNE INFILTRATION | associated_with | gene | 0.60 |
| MICRORNAS | associated_with | gene | 0.60 |
| AUTOPHAGY | associated_with | gene | 0.60 |
| AUTOPHAGY-RELATED GENES | associated_with | gene | 0.60 |
| AUTOPHAGY | interacts_with | gene | 0.60 |
| EXOSOMES | therapeutic_target | gene | 0.60 |
| MICRORNAS | therapeutic_target | gene | 0.60 |
| ALZHEIMER | therapeutic_target | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||