gene

GNAI3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GNAI3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

57Connections
0Hypotheses
0Analyses
19Outgoing
38Incoming

Summary

Comprehensive gene profile for GNAI3, a Gi/o family G protein alpha subunit involved in neuronal signaling, synaptic transmission, and neurodegenerative disease pathogenesis.

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🧬 Gene Info
Gene SymbolGNAI3
Full NameG Protein Subunit Alpha I3
AliasesG Protein Alpha i3
Chromosome1p31.3.
FunctionLigand binding to GPCR (e.g., dopamine D2, adenosine A1, muscarinic M2/M4)
Molecular Weight40 kDa
Amino Acids354 aa
UniProt ID[P08754](https://www.uniprot.org/uniprot/P08754)
Ensembl IDENSG00000165197
OMIM616377
GeneCardsGNAI3
Human Protein AtlasGNAI3
Associated DiseasesAls, Ms
InteractionsAKT, AKT1, GNB1, AMPD2, ATG5, MAVS
KG Connections57 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (19)

Knowledge base pages for this entity

Canonical Page

GNAI3 — G Protein Subunit Alpha I3

gene · 1732 words

gpcr-signaling

mechanism · 3284 words

ADCY3 — Adenylate Cyclase 3

gene · 2825 words

WDR81 — WD Repeat Domain 81

gene · 2168 words

GNG2 Gene

gene · 2140 words

NPY1R Gene

gene · 1930 words

Pathway Diagram

graph TD
    GNAI3["<b>GNAI3</b>"]
    Als{"Als"}
    GNAI3 -->|"associated with"| Als
    Ms{"Ms"}
    GNAI3 -->|"associated with"| Ms
    Cardiovascular{"Cardiovascular"}
    GNAI3 -->|"expressed in"| Cardiovascular
    WIPI1["WIPI1"]
    GNAI3 -->|"expressed in"| WIPI1
    Autophagy(["Autophagy"])
    GNAI3 -->|"associated with"| Autophagy
    GNAI3 -->|"interacts with"| Autophagy
    Wnt(["Wnt"])
    GNAI3 -->|"expressed in"| Wnt
    Akt(["Akt"])
    GNAI3 -->|"interacts with"| Akt
    neurodegeneration["neurodegeneration"]
    GNAI3 -->|"implicated in"| neurodegeneration
    MIRNAS["MIRNAS"]
    MIRNAS -->|"associated with"| GNAI3
    C9ORF72["C9ORF72"]
    C9ORF72 -->|"expressed in"| GNAI3
    CD8["CD8"]
    CD8 -->|"associated with"| GNAI3
    LRRK2["LRRK2"]
    LRRK2 -->|"expressed in"| GNAI3
    IMMUNE_INFILTRATION["IMMUNE INFILTRATION"]
    IMMUNE_INFILTRATION -->|"associated with"| GNAI3
    MICRORNAS["MICRORNAS"]
    MICRORNAS -->|"associated with"| GNAI3
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"associated with"| GNAI3
    GBA["GBA"]
    GBA -->|"expressed in"| GNAI3
    WDFY3["WDFY3"]
    WDFY3 -->|"expressed in"| GNAI3
    PIK3CB["PIK3CB"]
    PIK3CB -->|"expressed in"| GNAI3
    RALB["RALB"]
    RALB -->|"expressed in"| GNAI3
    AUTOPHAGY_RELATED_GENES["AUTOPHAGY-RELATED GENES"]
    AUTOPHAGY_RELATED_GENES -->|"associated with"| GNAI3
    style GNAI3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (19)

TargetRelationTypeStr
NLGN3mediatesprotein0.95
AKTactivatesprotein0.90
IL6inhibitsentity0.80
Alsassociated_withdisease0.65
Msassociated_withdisease0.65

Incoming (38)

SourceRelationTypeStr
GNAI2downregulatesgene0.70
C9ORF72expressed_ingene0.60
CD8associated_withgene0.60
LRRK2expressed_ingene0.60
GBAexpressed_ingene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found