| Gene Symbol | CLEC7A |
| Aliases | CLEC7APROTEIN |
| Protein Type | Receptor |
| Function | CLEC7A encodes a type II transmembrane protein with an extracellular C-type lectin domain and an intracellular immunoreceptor tyrosine-based activation motif (ITAM)-like hemITAM. |
| Subcellular Localization | </td><td>Plasma membrane (type II orientation)</td></tr> |
| Pathways | Amyloid, unfolded protein response, lipid metabolism |
| Ensembl ID | ENSG00000172243 |
| GeneCards | CLEC7A |
| Human Protein Atlas | CLEC7A |
| Myelin debris | During demyelination, exposed carbohydrate structures on damaged myelin are recognized by Dectin-1 |
| Amyloid-associated lipids | Modified lipoproteins in the plaque microenvironment |
| Protective | Promotes myelin debris phagocytosis, enabling remyelination by oligodendrocyte precursors |
| Pathogenic | Excessive Dectin-1 signaling can amplify inflammatory demyelination through IL-17 and GM-CSF production |
| Associated Diseases | Parkinson's disease, ischemic stroke |
| Interactions | Syk, TREM2, CTSB, CTSD, CTSL, GPNMB |
| KG Connections | 49 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |