gene

AXL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AXL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

201Connections

0Hypotheses

2Analyses

50Outgoing

48Incoming

Summary

AXL Receptor Tyrosine Kinase: TAM family receptor involved in cell survival, immune regulation, and neurodegenerative disease pathogenesis

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🧬 Gene Info

Gene Symbol	AXL
Full Name	AXL - AXL Receptor Tyrosine Kinase
Aliases	Page for AXL Protein
Chromosome	19q13.2
Protein Type	Gene
Function	is a receptor tyrosine kinase belonging to the TAM family (TYRO3, AXL, MERTK) that plays critical roles in cell survival, migration, immune regulation, and tissue homeostasis[@graham2014].
Primary Expression	immune cells, endothelial cells, neurons, and various peripheral tissues, where it mediates both ligand-dependent and ligand-independent signaling cas
Molecular Weight	140 kDa
Amino Acids	985 aa
Exons	20
Pathways	NF-κB, PI3K, MAPK
UniProt ID	Q9U6C5
NCBI Gene ID	55768
Ensembl ID	ENSG00000167601
GeneCards	AXL
Human Protein Atlas	AXL
Associated Diseases	Aging, Alzheimer, Cancer, INFLAMMATION, Ms, NEUROINFLAMMATION
Interactions	CHIT1, CXCL10, MMP12, CXCL1, EZH2, BRAF
KG Connections	201 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: AXL — AlphaFold Q9U6C5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    AXL["<b>AXL</b>"]
    Atherosclerosis{"Atherosclerosis"}
    AXL -->|"therapeutic target"| Atherosclerosis
    Als{"Als"}
    AXL -->|"inhibits"| Als
    Cardiovascular{"Cardiovascular"}
    AXL -->|"therapeutic target"| Cardiovascular
    Inflammation{"Inflammation"}
    AXL -->|"therapeutic target"| Inflammation
    ALS{"ALS"}
    AXL -->|"inhibits"| ALS
    AXL -->|"inhibits"| Inflammation
    AXL -->|"inhibits"| Cardiovascular
    AXL -->|"inhibits"| Atherosclerosis
    MMP12["MMP12"]
    AXL -->|"therapeutic target"| MMP12
    Innate_Immunity(["Innate Immunity"])
    AXL -->|"therapeutic target"| Innate_Immunity
    CHIT1["CHIT1"]
    AXL -->|"inhibits"| CHIT1
    CXCL1["CXCL1"]
    AXL -->|"therapeutic target"| CXCL1
    CXCL1 -->|"therapeutic target"| AXL
    CXCL10["CXCL10"]
    CXCL10 -->|"therapeutic target"| AXL
    CHIT1 -->|"inhibits"| AXL
    MMP12 -->|"therapeutic target"| AXL
    CXCL1 -->|"inhibits"| AXL
    CXCL9["CXCL9"]
    CXCL9 -->|"inhibits"| AXL
    AND["AND"]
    AND -->|"inhibits"| AXL
    MMP12 -->|"inhibits"| AXL
    style AXL fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (153)

Target	Relation	Type	Str
ds-83b31ef18d49	provides_data_for	dataset	1.00
IL-6	inhibits	gene	0.70
ADAM10	interacts_with	gene	0.65
GAS6	regulates	gene	0.65
JAK2	inhibits	gene	0.65
PROS1	activates	gene	0.65
Atherosclerosis	therapeutic_target	disease	0.65
Als	inhibits	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
ALS	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Cardiovascular	inhibits	disease	0.65
Atherosclerosis	inhibits	disease	0.65
Alzheimer	activates	disease	0.65
Ms	causes	disease	0.65
Cancer	causes	disease	0.65
Aging	causes	disease	0.65
Alzheimer	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Tumor	activates	disease	0.65
Aging	activates	disease	0.65
Senescence	activates	disease	0.65
Cancer	associated_with	disease	0.65
Aging	associated_with	disease	0.65
MICROGLIA	causes	cell_type	0.65
NEUROGENESIS	produces	phenotype	0.65
PARKINSON'S DISEASE	activates	disease	0.65
PARKINSON'S DISEASE	regulates	disease	0.65
NEUROINFLAMMATION	causes	phenotype	0.65
INFLAMMATION	regulates	phenotype	0.65
MICROGLIA	regulates	cell_type	0.65
NEUROINFLAMMATION	inhibits	phenotype	0.65
INFLAMMATION	protects_against	phenotype	0.65
FERROPTOSIS	protects_against	phenotype	0.65
AUTOPHAGY	activates	phenotype	0.65
DEMYELINATION	activates	phenotype	0.65
MICROGLIA	inhibits	cell_type	0.65
MACROPHAGE	regulates	cell_type	0.65
CYTOKINES	treats	phenotype	0.65
NEUROGENESIS	protects_against	phenotype	0.65
NEUROGENESIS	activates	phenotype	0.65
GLIOBLASTOMA	regulates	disease	0.65
APOPTOSIS	activates	phenotype	0.65
INFLAMMATION	causes	phenotype	0.65
DEMYELINATION	regulates	phenotype	0.65
MICROGLIA	treats	cell_type	0.65
MMP12	therapeutic_target	gene	0.60
CHIT1	inhibits	gene	0.60
CXCL1	therapeutic_target	gene	0.60

Incoming (48)

Source	Relation	Type	Str
ds-83b31ef18d49	data_in	dataset	1.00
GAS6	inhibits	gene	0.65
APOE	inhibits	gene	0.65
INFLAMMATION	activates	phenotype	0.65
MICROGLIA	protects_against	cell_type	0.65
FERROPTOSIS	regulates	phenotype	0.65
AUTOPHAGY	inhibits	phenotype	0.65
MICROGLIA	interacts_with	cell_type	0.65
CXCL1	therapeutic_target	gene	0.60
CXCL10	therapeutic_target	gene	0.60
CHIT1	inhibits	gene	0.60
MMP12	therapeutic_target	gene	0.60
CXCL1	inhibits	gene	0.60
MMP12	inhibits	gene	0.60
TNF	inhibits	gene	0.60
GAS6	activates	gene	0.60
APP	associated_with	gene	0.60
BMP2	activates	gene	0.60
GAS6	associated_with	gene	0.60
CXCL10	inhibits	gene	0.60
EZH2	activates	gene	0.60
CXCL9	inhibits	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
APP/PS1	associated_with	gene	0.60
AND	activates	gene	0.60
MICROGLIA	activates	gene	0.60
ALZHEIMER	associated_with	gene	0.60
CANCER	causes	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
INFLAMMATION	inhibits	gene	0.60
AGING	activates	gene	0.60
IL-6	therapeutic_target	gene	0.60
HER2	associated_with	gene	0.60
DISEASE-ASSOCIATED MICROGLIA	associated_with	gene	0.60
IL-6	inhibits	gene	0.60
MEK	activates	gene	0.60
ROS	activates	gene	0.60
CANCER	associated_with	gene	0.60
MICROGLIA	associated_with	gene	0.60
APOE	activates	gene	0.55
IBA1	expressed_in	gene	0.55
DEMYELINATION	depleted_in	phenotype	0.55
COMPLEMENT PATHWAY	associated_with	pathway	0.45
LOCUS COERULEUS	associated_with	brain_region	0.45
SPINAL CORD	associated_with	brain_region	0.45
PI3K/AKT PATHWAY	associated_with	pathway	0.45
CORTEX	associated_with	brain_region	0.45
benchmark_ot_ad_answer_key:AXL	data_in	dataset_row	0.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Why do TAM receptors protect against neuroinvasive viruses despite their known i

neuroinflammation | 2026-04-14 | 2 hypotheses Top: 0.499

Why do TAM receptors protect against neuroinvasive viruses despite their known i

neuroinflammation | 2026-04-13 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

AXL

Understanding Entity Pages

Summary

Wiki Pages (21)

AXL - AXL Receptor Tyrosine Kinase

Novel Therapy Index

TAM Receptor Signaling

Efferocytosis in Neurodegeneration

MERTK - MER Tyrosine Kinase

TYRO3 - TYRO3 Receptor Tyrosine Kinase

ALS Therapeutic Landscape — Programs by Phase and Modality

MS4A6A Gene

STAB1 Gene

Innate Immune Response in Neurodegeneration

CSF1R Modulation Therapy: Microglia Reset Protocol

CSF1R Inhibitors for Neurodegeneration

Axl Protein

TAM Receptor Modulation Therapy

PROS1 — Protein S (Vitamin K-Dependent Protein S)

Disease-Associated [Microglia](/cell-types/microglia-neuroinflammation) (DAM)

GAS6 - Growth Arrest Specific 6

Noradrenergic Signaling Pathway in Neurodegeneration

TLR7/8/9 Antagonists for Neurodegeneration

Microglia in Chronic Neuroinflammation

glial-cell-mechanisms

Pathway Diagram

Outgoing (153)

Incoming (48)

Targeting Hypotheses (0)

Mentioning Analyses (2)

Why do TAM receptors protect against neuroinvasive viruses despite their known i

Why do TAM receptors protect against neuroinvasive viruses despite their known i

Related Papers (0)