protein 1,249 words KG: DIAPH3 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

DIAPH3 Protein

🔬 Protein Info
Gene SymbolDIAPH3
Full NameDiaphanous Formin 3 (mDia1, DRF1)
AliasesDiaphanous Formin 3 (mDia1, DRF1)
Chromosome13q21.2
Protein FamilyFormin family
Functionis a member of the formin family of actin-nucleating proteins.
Subcellular LocalizationCytoplasm, Cytoskeleton, Membrane
Molecular Weight146 kDa
Amino Acids1193
Exons29
PathwaysNF-κB
UniProt IDQ9UQD0
GeneCardsDIAPH3
Human Protein AtlasDIAPH3
Protein NameDiaphanous Formin 3 (mDia1, DRF1)
Associated DiseasesANSD
KG Connections6 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (8)

APOE-Dependent Autophagy Restoration
Score: 0.61
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Cryptic Exon Silencing Restoration
Score: 0.46
Cross-Seeding Prevention Strategy
Score: 0.45
Glycine-Rich Domain Competitive Inhibition
Score: 0.43

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (6)

Packard Center for ALS Research
institution · KG edge: therapeutic_target
SYT1 — Synaptotagmin 1
gene · KG edge: associated_with
KCNH7 Gene
gene · KG edge: associated_with
GLI Gene Family
gene · KG edge: associated_with
Tumor Necrosis Factor (TNF)
entity · KG edge: therapeutic_target

Knowledge Graph (6 edges)

DIAPH3 associated_with SYT1
DIAPH3 therapeutic_target Als
DIAPH3 therapeutic_target Tumor
DIAPH3 therapeutic_target Glioblastoma
KCNH7 associated_with DIAPH3
GBM associated_with DIAPH3