gene 2,171 words KG: GBM 2026-03-27
kind:genesection:genestopic:alzheimerstopic:parkinsons
Contents

GLI Gene Family

🧬 Gene Info
Gene SymbolGBM
Full NameGlioma-Associated Oncogene Homolog
Chromosome3p25.1
Protein FamilyC2H2-type zinc finger transcription factors
Exons14
PathwaysAmyloid, Angiogenesis, Apoptosis, Autophagy, Blood-Brain Barrier
UniProt IDP08151
NCBI Gene ID2735
Ensembl IDENSG00000087495
GeneCardsGBM
Human Protein AtlasGBM
Chromosomal location3p25.1
Exon count14 exons
Alternative splicingProduces full-length activator (GLI3A) and truncated repressor (GLI3R)
Promoter architectureContains GLI-binding sites that enable autoregulation
Associated DiseasesAD, ALI, ALS, Aging, Alzheimer
Known Drugs/Compoundsquercetin, SSRI
InteractionsSOAT1, DGAT1, STING, CGAS, RAC1, PAK1
KG Connections1411 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (30)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
APOE-Dependent Autophagy Restoration
Score: 0.61
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
Circadian Clock-Autophagy Synchronization
Score: 0.55

Related Analyses (10)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

Related Experiments (2)

scRNA-seq analysis of human atherosclerotic plaques
exploratory · proposed · Score: 0.90
Machine learning-based identification of C1Q hub genes
exploratory · proposed · Score: 0.90

See Also (5)

Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
Alzheimer Indonesia
institution · KG edge: activates
AIM2 Inflammasome Modulation Therapy for Neurodegenerat
idea · KG edge: associated_with
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: associated_with
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: inhibits

Knowledge Graph (12 edges)

GBM regulates CIRCADIAN_RHYTHM
GBM associated_with C1Q
GBM associated_with C1QA
GBM associated_with C1QC
GBM associated_with SPI1
GBM associated_with APOE
GBM associated_with LC3
GBM associated_with EPG5
GBM associated_with STX17
GBM associated_with SQSTM1