| Gene Symbol | DLAT |
| Full Name | Dihydrolipoamide S-Acetyltransferase |
| Aliases | DLATPROTEIN |
| Chromosome | 11q23.1 |
| Function | DLAT is the central structural and catalytic component of the pyruvate dehydrogenase complex, forming a 24-mer cubic core that organizes the entire complex[@patel2014] |
| Subcellular Localization | </strong></td><td>Mitochondrial matrix</td></tr> |
| Pathways | Akt, Apoptosis, Immune Response, Pi3K/Akt, apoptosis |
| UniProt ID | [P10515](https://www.uniprot.org/uniprot/P10515) |
| Ensembl ID | ENSG00000150768 |
| OMIM | 608770 |
| GeneCards | DLAT |
| Human Protein Atlas | DLAT |
| Glucose oxidation | PDH complex links glycolysis to the TCA cycle by converting pyruvate to acetyl-CoA |
| ATP production | The acetyl-CoA generated feeds into the TCA cycle, producing NADH and FADH2 for oxidative phosphorylation |
| Biosynthetic precursor | Acetyl-CoA is also used for fatty acid synthesis and cholesterol biosynthesis |
| Associated Diseases | Alzheimer's disease |
| Interactions | AKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK, AND, APOPTOSIS |
| KG Connections | 69 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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