| Gene Symbol | HK2 |
| Full Name | Hexokinase 2 |
| Aliases | HK2PROTEIN |
| Chromosome | 2p12 |
| Protein Family | Hexokinase family (HK1-4) |
| Protein Type | Enzyme |
| Target Class | Enzyme |
| Function | Small molecule inhibitor of glucose phosphorylation |
| Mechanism of Action | Small molecule inhibitor of glucose phosphorylation |
| Primary Expression | Brain, Muscle, Fat |
| Subcellular Localization | Mitochondrial outer membrane (bound to VDAC) |
| Druggability | Low (0.38) |
| Clinical Stage | Phase III |
| Pathways | Akt, Apoptosis, Epigenetic, Erk Signaling, Glucose Metabolism |
| UniProt ID | P19367 |
| NCBI Gene ID | 3099 |
| Ensembl ID | ENSG00000149718 |
| GeneCards | HK2 |
| Human Protein Atlas | HK2 |
| Associated Diseases | ALS, Acute Kidney Injury, Alzheimer, Alzheimer's disease, Cancer |
| Known Drugs/Compounds | ADUCANUMAB, aducanumab |
| Interactions | MYC, FASN, HK1, AKT, SRC, SPR |
| SciDEX Target | View Target Profile (10 clinical trials) |
| SciDEX Hypotheses | Metabolic Switch Targeting for A1→A2 Repolarizatio Metabolic Reprogramming via Microglial Glycolysis |
| KG Connections | 810 knowledge graph edges |
| Databases | GeneCardsHPASTRING |