concept

ACC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ACC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

139Connections

4Hypotheses

10Analyses

50Outgoing

34Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	ACC
Key Genes/Proteins	AMPK, PV
Related Diseases	Als, Ms, Atherosclerosis, Autism, Tumor
Related Pathways	Polyunsaturated Fatty Acid Biosynthesis
Linked Hypotheses	5 hypotheses

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ACC["ACC"]
    ACC -->|"inhibits"| Als["Als"]
    ACC -->|"inhibits"| Ms["Ms"]
    ACC -->|"expressed in"| Atherosclerosis["Atherosclerosis"]
    ACC -->|"inhibits"| Tumor["Tumor"]
    ACC -->|"target for"| Fatty_Liver["Fatty Liver"]
    ACC -->|"inhibits"| ULK1["ULK1"]
    ACC -->|"activates"| AMPK["AMPK"]
    ACC -->|"inhibits"| Autophagy["Autophagy"]
    AMPK -->|"activates"| ACC
    KRAS["KRAS"] -->|"inhibits"| ACC
    ERK["ERK"] -->|"expressed in"| ACC
    CD36["CD36"] -->|"expressed in"| ACC
    FAS["FAS"] -->|"expressed in"| ACC
    SCD1["SCD1"] -->|"expressed in"| ACC
    SPR["SPR"] -->|"target for"| ACC
    LDL["LDL"] -->|"target for"| ACC

Outgoing (105)

Target	Relation	Type	Str
Polyunsaturated Fatty Acid Biosynthesis	regulates	pathway	0.85
Hepatic Lipogenesis	regulates	process	0.80
PV	regulates	gene	0.70
Als	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Als	therapeutic_target	disease	0.65
Atherosclerosis	expressed_in	disease	0.65
Autism	associated_with	disease	0.65
Als	associated_with	disease	0.65
Tumor	inhibits	disease	0.65
Cancer	associated_with	disease	0.65
Lung Cancer	associated_with	disease	0.65
Fatty Liver	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Carcinoma	associated_with	disease	0.65
Tumor	activates	disease	0.65
Cancer	inhibits	disease	0.65
Neuroinflammation	activates	disease	0.65
ALS	activates	disease	0.65
Inflammation	activates	disease	0.65
Metabolic Syndrome	activates	disease	0.65
Ferroptosis	activates	disease	0.65
Stroke	activates	disease	0.65
ULK1	inhibits	gene	0.60
AMPK	activates	gene	0.60
Autophagy	inhibits	pathway	0.60
ERK	expressed_in	gene	0.60
FAS	expressed_in	gene	0.60
CD36	expressed_in	gene	0.60
SPR	therapeutic_target	gene	0.60
SCD1	expressed_in	gene	0.60
Lipid Metabolism	therapeutic_target	pathway	0.60
ABCA1	expressed_in	gene	0.60
DHCR24	expressed_in	gene	0.60
LDLR	expressed_in	gene	0.60
SREBF2	expressed_in	gene	0.60
LPL	expressed_in	gene	0.60
HMGCR	expressed_in	gene	0.60
Lipid Metabolism	expressed_in	pathway	0.60
Cholesterol	expressed_in	pathway	0.60
AUTOPHAGY	inhibits	gene	0.60
MITOCHONDRIAL DYSFUNCTION	associated_with	gene	0.60
ACETYL-COA	therapeutic_target	gene	0.60
Oxidative Stress	activates	pathway	0.60
ARNT2	inhibits	gene	0.60
Interneuron	regulates	cell_type	0.60
Neuron	regulates	cell_type	0.60
Pyramidal	regulates	cell_type	0.60
NEURON	regulates	gene	0.60
KCNH7	interacts_with	gene	0.60

Incoming (34)

Source	Relation	Type	Str
AMPK	phosphorylates	protein	0.90
AMPK	activates	gene	0.64
KRAS	inhibits	gene	0.60
CANCER	associated_with	gene	0.60
ERK	expressed_in	gene	0.60
CD36	expressed_in	gene	0.60
FAS	expressed_in	gene	0.60
SCD1	expressed_in	gene	0.60
SPR	therapeutic_target	gene	0.60
LDL	therapeutic_target	gene	0.60
DNA	associated_with	gene	0.60
AND	inhibits	gene	0.60
CANCER	inhibits	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
PTP1B	associated_with	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
JNK1	activates	gene	0.60
ATP	activates	gene	0.60
GAIN	activates	gene	0.60
AND	activates	gene	0.60
JNK	activates	gene	0.60
SST	regulates	gene	0.60
STROKE	activates	gene	0.60
ROS	inhibits	gene	0.60
DLK1	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
ARNT2	inhibits	gene	0.60
AND	regulates	gene	0.60
SHANK3	interacts_with	gene	0.60
KCNH7	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
NEURON	regulates	gene	0.60
metformin	targets	drug	0.60

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TREM2 R47H Metabolic Lock-in at Cholesterol Ester Accumulati	0.563	neuroimmunology	What is the temporal sequence of TREM2 s
Chromatin Accessibility Restoration via BRD4 Modulation	0.559	neurodegeneration	Epigenetic reprogramming in aging neuron
SGMS1-Driven Sphingomyelin Accumulation Impairs BACE1 Lysoso	0.542	neurodegeneration	What molecular mechanisms link elevated
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m	0.348	neurodegeneration	Mitochondrial transfer between astrocyte

Mentioning Analyses (10)

Scientific analyses that reference this entity

How do sphingomyelin/ceramide ratios specifically regulate BACE1 clustering and

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.596

Extracellular vesicle biomarkers for early AD detection

neurodegeneration | 2026-04-12 | 0 hypotheses

Can nanobodies achieve selective membrane penetration into tau-containing vesicl

molecular biology | 2026-04-09 | 0 hypotheses

Which specific post-translational modifications on pathological tau create drugg

neurodegeneration | 2026-04-09 | 0 hypotheses

What are the neuron-specific effects of ALS-causing mutations on autophagy machi

neurodegeneration | 2026-04-08 | 0 hypotheses

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
KIF5A de novo mutation associated with myoclonic seizures and neonatal onset pro [PMID:27414745]	Rydzanicz M, Jagła M, Kosinska J, Tomasi	Clin Genet	2017	1
TRAK/Milton motor-adaptor proteins steer mitochondrial trafficking to axons and [PMID:23395375]	van Spronsen M, Mikhaylova M, Lipka J, S	Neuron	2013	1
Delineation of the TRAK binding regions of the kinesin-1 motor proteins. [PMID:24161670]	Randall TS, Moores C, Stephenson FA	FEBS Lett	2013	1
Sertad4 Regulates Pathological Cardiac Remodeling. [PMID:41889836]	Francois A, Bermeo-Blanco O, Nguyen BT,	bioRxiv : the preprint server	2026	0
Hsp70-Targeting Chimeras Enable Dual Proteasomal and Lysosomal Degradation of In [PMID:41874277]	Wang Z, Li P, Yin F, Zhang H, Wang S, Te	Journal of medicinal chemistry	2026	0
Cartilage targeting hydrogel nanoplatform degrades BRD4 to alleviate osteoarthri [PMID:41904167]	Zhao Q, Xu T, Du Z, Lu X, Zhang Y, Peng	Nature communications	2026	0
Semi-rigid linkers improve the pharmacokinetic properties and therapeutic effica [PMID:41687266]	Yu S, Hu S, Wang W, Pan C, Zhang H et al	Eur J Med Chem	2026	0
Molecular insights for the tumor suppressor role of SPOP in prostate cancer. [PMID:41707797]	Yan P, Xue X, Hou T, Wang J, Jiang W et	Biochim Biophys Acta Rev Cance	2026	0
Nutrient-driven histone acetylation underlies energy storage and mobilization. [PMID:41786244]	Chen L, Zhu L, Xiao H, Wang X, Xia F et	Mol Metab	2026	0
D-MBIS Nonbonded Force Field Parameters Improve Specificity and Selectivity Pred [PMID:41849667]	Macaya L, Vöhringer-Martinez E	J Phys Chem B	2026	0
BRD4 directs myofiber identity and metabolic adaptation through CHD4 cooperation [PMID:41957025]	Zhou Z, Liu L, Xu Z, Zhou D, Liu A et al	Nat Commun	2026	0
Harnessing FBXO31 with Terminal Amide-Functionalized Molecules for Targeted Prot [PMID:41963263]	Zhang C, Jin X, Zhou C, Jenkins MJ, Riha	J Am Chem Soc	2026	0
Designing an Osmium(II) Complex to Inhibit the Growth and Recurrence of Tumors b [PMID:41964570]	Zhu M, Jiang M, Liao W, Qi K, Li G et al	J Med Chem	2026	0
Design, synthesis and evaluation of novel BRD4 and RIPK3 dual inhibitors as pote [PMID:41966492]	Moukha-Chafiq O, Yatchang MF, Houghtling	Bioorg Med Chem Lett	2026	0
Alkyne Two-Phase Strategy: Rapid Generation of TK-285-Derived PROTACs as BRD4 De [PMID:41852276]	Yamakoshi H, Watanabe R, Segawa R, Ishih	Journal of medicinal chemistry	2026	0
The epigenetic and epitranscriptomic regulation of Brd4-Mettl3 axis on STING med [PMID:41917296]	Zhao J, Luo X, Wang Z, Luo W, Wu S, Ma X	Inflammation research : offici	2026	0
Punicalagin with anti-inflammatory activities affects Brd-4 mediated chromatin r [PMID:41807492]	Li H, Li Q, Wan T, Wang Y, Zhang S	Scientific reports	2026	0
Targeting BRD4-A Promising Therapeutic Option for Glioblastoma? [PMID:41828493]	Lindner M, Lisińska D, Kędzierzyńska A,	International journal of molec	2026	0
High-intensity interval training alleviates COPD-induced gastrocnemius muscle dy [PMID:41865095]	Zhu C, Peng W, Yang L, Zhang W	Journal of muscle research and	2026	0
A photothermal immune hydrogel dressing for enhanced post-melanoma resection tre [PMID:41877232]	Tan D, Zhu W, Liu S, Liao F, Xu X, Luo J	Journal of nanobiotechnology	2026	0

ACC

Understanding Entity Pages

Wiki Pages (21)

acc-chronic-pain

Spinal Cord Stimulation-Affected Neurons

ventral-anterior-thalamic-nucleus

Allen Human Brain Atlas

Infantile Neuroaxonal Dystrophy (INAD)

reward-circuit

Pathway Diagram

Outgoing (105)

Incoming (34)

Targeting Hypotheses (4)

Mentioning Analyses (10)

How do sphingomyelin/ceramide ratios specifically regulate BACE1 clustering and

Extracellular vesicle biomarkers for early AD detection

Can nanobodies achieve selective membrane penetration into tau-containing vesicl

Which specific post-translational modifications on pathological tau create drugg

What are the neuron-specific effects of ALS-causing mutations on autophagy machi

Why do structurally diverse sugars (trehalose, melibiose, lactulose) produce ide

Cell type vulnerability debate in Alzheimer's disease (SEA-AD v4)

Extracellular vesicle biomarkers for early AD detection

Is disrupted sleep a cause or consequence of neurodegeneration? Analyze the bidi

Is disrupted sleep a cause or consequence of neurodegeneration? Analyze the bidi

Related Papers (20)

ACC

Understanding Entity Pages

Wiki Pages (21)

acc-chronic-pain

Spinal Cord Stimulation-Affected Neurons

ventral-anterior-thalamic-nucleus

Allen Human Brain Atlas

Infantile Neuroaxonal Dystrophy (INAD)

reward-circuit

Methylphenidate + iTBS for Apathy in AD (PRIME Trial)

Non-Dopaminergic Neurotransmitter Degeneration as Upstream Driver in Parkinson's Disease

HLCS Gene

AMPK Signaling Pathway

[AD](/diseases/alzheimers-disease) Failed Approaches Analysis

Peripheral Nerve Stimulation-Affected Neurons

Neuritic Plaques

VPS13C Protein

Circuit Rankings

Spinal Cord Lamina I Pain Neurons

Cerebral Amyloid Angiopathy Pathway in Neurodegeneration

Frontoparietal Control Network

TUBB2A — Tubulin Beta 2A Class IIa

accelerated-tms-apathy-pd-nct07399496

Spinothalamic Neurons

Pathway Diagram

Outgoing (105)

Incoming (34)

Targeting Hypotheses (4)

Mentioning Analyses (10)

How do sphingomyelin/ceramide ratios specifically regulate BACE1 clustering and

Extracellular vesicle biomarkers for early AD detection

Can nanobodies achieve selective membrane penetration into tau-containing vesicl

Which specific post-translational modifications on pathological tau create drugg

What are the neuron-specific effects of ALS-causing mutations on autophagy machi

Why do structurally diverse sugars (trehalose, melibiose, lactulose) produce ide

Cell type vulnerability debate in Alzheimer's disease (SEA-AD v4)

Extracellular vesicle biomarkers for early AD detection

Is disrupted sleep a cause or consequence of neurodegeneration? Analyze the bidi

Is disrupted sleep a cause or consequence of neurodegeneration? Analyze the bidi

Related Papers (20)