| Gene Symbol | HUWE1 |
| Full Name | HECT, UBA and WWE Domain Containing E3 Ubiquitin Protein Ligase 1 |
| Chromosome | Xp11.22 |
| Protein Family | HECT-domain E3 ubiquitin ligases |
| Protein Type | Ligase |
| Function | It recognizes and ubiquitinates misfolded and damaged proteins for proteasomal degradation, preventing inclusion body formation by rapidly ubiquitinating aggregation-prone species. |
| Primary Expression | the brain throughout development and adulthood, with complex transcriptional regulation by Myc, E2F, and activity-dependent transcription factors[@zho |
| Subcellular Localization | Cytoplasm, nucleus, mitochondria-associated |
| Molecular Weight | ~482 kDa |
| Amino Acids | 374 aa |
| Exons | 85 |
| Pathways | mTOR |
| UniProt ID | Q7Z6Z7 |
| NCBI Gene ID | 10075 |
| Ensembl ID | ENSG00000086758 |
| OMIM | 300697 |
| GeneCards | HUWE1 |
| Human Protein Atlas | HUWE1 |
| Associated Diseases | ALS |
| Interactions | IL1B, LC3, MUL1, NLRP3, OPA1, PARL |
| KG Connections | 55 knowledge graph edges |
| Databases | GeneCardsHPASTRING |