protein

AMBRA1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AMBRA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1112Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

AMBRA1 is a protein involved in neurodegeneration research. Key relationships include: interacts with, associated with, regulates. Associated with AD, ALI, ALS. Connected to 563 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	AMBRA1
Aliases	AMBRA1, KIAA1731
Chromosome	11p15.5
Protein Family	WD40 repeat-containing proteins
Function	encodes a critical positive regulator of autophagy that plays essential roles in cellular homeostasis, development, and disease pathogenesis[@cecconi2008][@fimia2012].
Gene Type	Protein-coding
Pathways	Akt, Apoptosis, Autophagy, Cell Cycle, Immune Response
UniProt ID	Q9C0A1
NCBI Gene ID	55626
Ensembl ID	ENSG00000164024
GeneCards	AMBRA1
Human Protein Atlas	AMBRA1
Gene Name	Activating Molecule in Beclin 1-Regulated Autophagy 1
Approach	Model
AAV-AMBRA1	PD model
Associated Diseases	AD, ALI, ALS, ALZHEIMER'S DISEASE, Age-Related Macular Degeneration
Known Drugs/Compounds	rapamycin
Interactions	PINK1, BCL2L13, NLRP3, ABCD3, FIP200, RTN3
KG Connections	1112 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: AMBRA1 — AlphaFold Q9C0A1 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    AMBRA1["AMBRA1"] -->|"regulates"| FAS["FAS"]
    AMBRA1["AMBRA1"] -->|"regulates"| ribosome_protein_biosynthesis["ribosome protein biosynthesis"]
    AMBRA1["AMBRA1"] -->|"regulates"| T_cell_death["T cell death"]
    AMBRA1["AMBRA1"] -->|"protects against"| MAPK_inhibitor_resistance["MAPK inhibitor resistance"]
    AMBRA1["AMBRA1"] -.->|"inhibits"| FAK1["FAK1"]
    AMBRA1["AMBRA1"] -->|"modifies"| Smad4["Smad4"]
    CD28_PI3K_mTORC1_EIF4F_pathway["CD28-PI3K-mTORC1-EIF4F pathway"] -->|"regulates"| AMBRA1["AMBRA1"]
    USP7["USP7"] -->|"modifies"| AMBRA1["AMBRA1"]
    TCR["TCR"] -->|"regulates"| AMBRA1["AMBRA1"]
    CAT["CAT"] -->|"interacts"| AMBRA1["AMBRA1"]
    style AMBRA1 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (799)

Target	Relation	Type	Str
BECLIN1	interacts_with	protein	0.95
FAS	regulates	protein	0.90
ribosome protein biosynthesis	regulates	pathway	0.90
T cell death	regulates	phenotype	0.90
MAPK inhibitor resistance	protects_against	phenotype	0.90
FAK1	inhibits	protein	0.90
Smad4	modifies	protein	0.90
epithelial-to-mesenchymal transition	activates	pathway	0.90
breast cancer metastasis	causes	disease	0.90
cyclin D	inhibits	protein	0.90
S-phase entry	regulates	pathway	0.90
genomic integrity	protects_against	phenotype	0.90
replication stress	protects_against	phenotype	0.90
NRF2	inhibits	protein	0.90
DUB3	inhibits	protein	0.90
colitis	causes	disease	0.90
CDK6	inhibits	protein	0.90
Macroautophagy	activates	process	0.90
TGF-beta signaling	activates	pathway	0.90
oxidative stress	causes	phenotype	0.90
autophagy pathway	participates_in	pathway	0.90
Cell Proliferation	regulates	process	0.85
PARKINSON'S DISEASE	associated_with	disease	0.85
ALZHEIMER'S DISEASE	associated_with	disease	0.85
NEURODEGENERATION	involved_in	process	0.85
melanoma	protects_against	disease	0.80
TFEB	inhibits	protein	0.80
TFE3	inhibits	protein	0.80
Parkinson Disease	associated_with	disease	0.80
aging-related diseases	implicated_in	disease	0.80
Alzheimer Disease	associated_with	disease	0.80
ATG	activates	gene	0.80
oxidative stress response	participates_in	pathway	0.80
apoptosis pathway	participates_in	pathway	0.80
neural stem cells	activates	cell_type	0.80
neural stem cells	regulates	cell_type	0.80
Autophagy	regulates	pathway	0.80
Muscular Dystrophy	associated_with	disease	0.78
Age-Related Macular Degeneration	associated_with	disease	0.78
Parkinson	associated_with	disease	0.75
Aging	regulates	disease	0.75
Apoptosis	involved_in	process	0.75
autophagy	regulates	process	0.70
age-related macular degeneration	associated_with	disease	0.70
HMGB1	interacts_with	gene	0.70
muscular dystrophy	associated_with	disease	0.70
CTSD	regulates	gene	0.70
MAP1LC3B	regulates	gene	0.70
AMPK signaling	participates_in	pathway	0.70
Autophagy	interacts_with	pathway	0.70

Incoming (313)

Source	Relation	Type	Str
BCL2	binds	protein	0.95
CD28-PI3K-mTORC1-EIF4F pathway	regulates	pathway	0.90
USP7	modifies	protein	0.90
TCR	regulates	protein	0.90
AUTOPHAGY	regulates	gene	0.80
PI3K	activates	gene	0.70
BCL-2	interacts_with	gene	0.70
AUTOPHAGY	interacts_with	gene	0.70
CAT	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
DNM1L	interacts_with	gene	0.60
CANX	interacts_with	gene	0.60
LGALS3	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
PEX3	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
BCL2	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
TAX1BP1	interacts_with	gene	0.60
ATM	interacts_with	gene	0.60
SNCAIP	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
MFN1	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
PARKIN	interacts_with	gene	0.60
FMR1	interacts_with	gene	0.60
SNCA	interacts_with	gene	0.60
FAM134B	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
EPAS1	interacts_with	gene	0.60
MIRO1	interacts_with	gene	0.60
CTSD	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
EIF2AK3	interacts_with	gene	0.60
PRKN	interacts_with	gene	0.60
BCL2L11	interacts_with	gene	0.60
MUL1	interacts_with	gene	0.60
BNIP3	interacts_with	gene	0.60
DISC1	interacts_with	gene	0.60
EIF2S1	interacts_with	gene	0.60
RIPK3	interacts_with	gene	0.60
DRP1	interacts_with	gene	0.60
CHOP	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
PTEN	interacts_with	gene	0.60
DDIT3	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
EMD	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

AMBRA1

Understanding Entity Pages

Summary

Wiki Pages (21)

AMBRA1 Gene

Autophagy Mechanisms

mitophagy-defect

autophagy-lysosomal-alzheimers

RICTOR Protein

pink1-parkin-mitophagy-pd-causal-chain

GBA Gene Mutations and Parkinson's Disease Risk

Beclin-1 Protein

erk-mapk-signaling-neurodegeneration

Autophagy Enhancement for Tauopathy

Cell Types

CBS Autophagy-Lysosomal Pathway Dysfunction

BECN1 Protein (Beclin-1)

Autophagy-Lysosomal Dysfunction in Neurodegenerative Diseases

Mitophagy Receptor Pathway in Neurodegeneration

DEPTOR

RICTOR Gene

DDB1 — DNA Damage Binding Protein 1

MAVS Gene