protein 1,204 words KG: MECOMPROTEIN 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

MECOM Gene — MDS1 and EVI1 Complex

🔬 Protein Info
Gene SymbolMECOM
Chromosome3q26
Protein FamilyC2H2 zinc finger transcription factors
Protein TypeTranscription Factor
FunctionThe MECOM gene encodes a protein involved in various neurological processes.
Primary Expressionvarious brain regions including cortex, hippocampus, and cerebellum
Subcellular LocalizationNuclear
Molecular Weight145 kDa (full-length EVI1)
Amino Acids725 aa
Exons16
PathwaysTGF-β signaling
UniProt IDQ9Y6Q5
NCBI Gene ID2122
Ensembl IDENSG00000085276
GeneCardsMECOM
Human Protein AtlasMECOM
Associated Diseasesneurodegeneration
InteractionsTRIM25, EGFR, CANCER, HOXA10-HOXA9, SPINK1, AND
KG Connections10 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (10)

Purinergic Signaling Polarization Control
Score: 0.55
Mechanosensitive Ion Channel Reprogramming
Score: 0.51
Lipid Droplet Dynamics as Phenotype Switches
Score: 0.46
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51

Related Analyses (10)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

Related Experiments (1)

Down Syndrome Alzheimer's Disease: Mechanisms and Therapeuti
clinical · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
ALS Therapeutic Landscape — Programs by Phase and Modal
disease · Pages share 3 hypotheses
Wnt/β-Catenin Signaling Pathway in Neurodegeneration
mechanism · Pages share 3 hypotheses
WNK1-Bilirubin Signaling in Neuroinflammation and Neuro
mechanism · Pages share 3 hypotheses
vip-vasoactive-intestinal-peptide-signaling-neurodegene
mechanism · Pages share 3 hypotheses