concept

SPINK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SPINK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

29Connections
0Hypotheses
0Analyses
24Outgoing
5Incoming

No summary available yet. View on Wiki →

💡 Concept Info
NameSPINK1
Key Genes/ProteinsMECOM, CANCER, HOXA10-HOXA9, NEURODEGENERATION, PARKINSON'S DISEASE, PARKINSON
Related DiseasesCancer, Tumor, Parkinson, Aging, Neuroinflammation
Related PathwaysEGFR signaling

Wiki Pages (1)

Knowledge base pages for this entity

MECOM Gene

gene · 669 words

Pathway Diagram

graph TD
    SPINK1["SPINK1"]
    SPINK1 -->|"activates"| EGFR_signaling["EGFR signaling"]
    SPINK1 -->|"activates"| Cancer["Cancer"]
    SPINK1 -->|"activates"| Tumor["Tumor"]
    SPINK1 -->|"activates"| Parkinson["Parkinson"]
    SPINK1 -->|"activates"| Aging["Aging"]
    SPINK1 -->|"activates"| Neuroinflammation["Neuroinflammation"]
    SPINK1 -->|"activates"| Inflammation["Inflammation"]
    SPINK1 -->|"activates"| Alzheimer["Alzheimer"]
    MECOM["MECOM"] -->|"activates"| SPINK1
    TRIM25["TRIM25"] -->|"activates"| SPINK1
    EGFR["EGFR"] -->|"activates"| SPINK1
    PTEN["PTEN"] -->|"activates"| SPINK1
    PINK1["PINK1"] -->|"expressed in"| SPINK1

Outgoing (24)

TargetRelationTypeStr
EGFR signalingactivatespathway0.90
Canceractivatesdisease0.65
Tumoractivatesdisease0.65
Parkinsonactivatesdisease0.65
Agingactivatesdisease0.65

Incoming (5)

SourceRelationTypeStr
MECOMactivatesprotein0.90
TRIM25activatesgene0.60
EGFRactivatesgene0.60
PTENactivatesgene0.60
PINK1expressed_ingene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found