Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SPINK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No summary available yet. View on Wiki →
| Name | SPINK1 |
| Key Genes/Proteins | MECOM, CANCER, HOXA10-HOXA9, NEURODEGENERATION, PARKINSON'S DISEASE, PARKINSON |
| Related Diseases | Cancer, Tumor, Parkinson, Aging, Neuroinflammation |
| Related Pathways | EGFR signaling |
Knowledge base pages for this entity
graph TD
SPINK1["SPINK1"]
SPINK1 -->|"activates"| EGFR_signaling["EGFR signaling"]
SPINK1 -->|"activates"| Cancer["Cancer"]
SPINK1 -->|"activates"| Tumor["Tumor"]
SPINK1 -->|"activates"| Parkinson["Parkinson"]
SPINK1 -->|"activates"| Aging["Aging"]
SPINK1 -->|"activates"| Neuroinflammation["Neuroinflammation"]
SPINK1 -->|"activates"| Inflammation["Inflammation"]
SPINK1 -->|"activates"| Alzheimer["Alzheimer"]
MECOM["MECOM"] -->|"activates"| SPINK1
TRIM25["TRIM25"] -->|"activates"| SPINK1
EGFR["EGFR"] -->|"activates"| SPINK1
PTEN["PTEN"] -->|"activates"| SPINK1
PINK1["PINK1"] -->|"expressed in"| SPINK1| Target | Relation | Type | Str |
|---|---|---|---|
| EGFR signaling | activates | pathway | 0.90 |
| Cancer | activates | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| Parkinson | activates | disease | 0.65 |
| Aging | activates | disease | 0.65 |
| Neuroinflammation | activates | disease | 0.65 |
| Inflammation | activates | disease | 0.65 |
| Alzheimer | activates | disease | 0.65 |
| Neurodegeneration | activates | disease | 0.65 |
| CANCER | activates | gene | 0.60 |
| HOXA10-HOXA9 | activates | gene | 0.60 |
| NEURODEGENERATION | activates | gene | 0.60 |
| PARKINSON'S DISEASE | activates | gene | 0.60 |
| PARKINSON | activates | gene | 0.60 |
| ALZHEIMER | activates | gene | 0.60 |
| ALZHEIMER'S DISEASE | activates | gene | 0.60 |
| UBIQUITIN | activates | gene | 0.60 |
| AGING | activates | gene | 0.60 |
| NEUROINFLAMMATION | activates | gene | 0.60 |
| Proteasome | causes | pathway | 0.60 |
| AND | activates | gene | 0.60 |
| MECOM | activates | gene | 0.60 |
| EGFR | activates | gene | 0.60 |
| TRIM25 | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||