protein 639 words KG: NEMO 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

NEMO/IKKγ Protein

🔬 Protein Info
Gene SymbolNEMO
Protein FamilyIKK kinase complex
Protein TypeKinase
FunctionNEMO (IKKγ) is the regulatory subunit of the IKK complex.
Molecular Weight48 kDa
PathwaysNF-kB signaling, NF-κB signaling, oxidative stress response
UniProt ID[Q9Y578](https://www.uniprot.org/uniprot/Q9Y578)
GeneCardsNEMO
Human Protein AtlasNEMO
Associated Diseasesneurodegeneration
InteractionsPARKIN, P62, OPTN, OPTINEURIN, NF-ΚB, OXIDATIVE STRESS
KG Connections78 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (6)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Prefrontal sensory gating circuit restoration via PV interne
Score: 0.78
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.67
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (7)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

See Also (7)

Mitophagy Receptor Pathway in Neurodegeneration
mechanism · KG edge: interacts_with
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: contributes_to
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: interacts_with
astrocyte-neuron-metabolic-coupling-parkinsons
general · KG edge: expressed_in
Mitochondria
entity · KG edge: activates

Knowledge Graph (12 edges)

NEMO regulates OPTINEURIN
NEMO regulates OPTN
NEMO regulates PARKIN
NEMO expressed_in OPTN
NEMO expressed_in P62
NEMO expressed_in SQSTM1
NEMO interacts_with PARKIN
NEMO interacts_with P62
NEMO interacts_with OPTN
NEMO interacts_with OPTINEURIN

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