protein

IKK

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IKK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

80Connections

0Hypotheses

0Analyses

50Outgoing

19Incoming

Summary

Page for IKK Protein

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🔬 Protein Info

Gene Symbol	IKK
Function	Ikk Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Subcellular Localization	to Cytoplasm; nucleus upon activation and plays a significant role in the pathog
Molecular Weight	87 kDa
Pathways	NF-κB, NF-κB pathway
GeneCards	IKK
Human Protein Atlas	IKK
Associated Diseases	ALS, Alzheimer, Parkinson
Known Drugs/Compounds	rapamycin, metformin
Interactions	P2X7, IRGM1, LC3, MAP1LC3, MAPK, MELK
KG Connections	80 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

flowchart TD
    IKK(["IKK"])
    NEMO(["NEMO"])
    PER2(["PER2"])
    p65(["p65"])
    NF__B(["NF-kappaB"])

    NEMO -->|"associated with"| IKK
    PER2 -->|"promotes"| IKK
    IKK -->|"phosphorylates"| p65
    IKK -->|"activates"| NF__B
    NEMO -->|"activates"| IKK

    style IKK fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (61)

Target	Relation	Type	Str
NFKB	interacts_with	protein	0.95
p65	phosphorylates	protein	0.85
NF-κB	activates	protein	0.70
MAPK signaling	participates_in	pathway	0.70
NF-kB signaling	participates_in	pathway	0.65
ALS	associated_with	disease	0.60
Parkinson	associated_with	disease	0.60
Alzheimer	associated_with	disease	0.60
IRGM1	activates	gene	0.60
LC3	activates	gene	0.60
MAP1LC3	activates	gene	0.60
MAPK	activates	gene	0.60
MELK	activates	gene	0.60
MTOR	activates	gene	0.60
NLR	activates	gene	0.60
NLRP3	activates	gene	0.60
NOD2	activates	gene	0.60
NRBF2	activates	gene	0.60
PI3K	activates	gene	0.60
PYCARD	activates	gene	0.60
RALGAPA2	activates	gene	0.60
RIPK2	activates	gene	0.60
RIPK3	activates	gene	0.60
SMARCA4	activates	gene	0.60
SNF	activates	gene	0.60
SQSTM1	activates	gene	0.60
STAT3	activates	gene	0.60
SWI	activates	gene	0.60
TNF	activates	gene	0.60
TNFA	activates	gene	0.60
ULK1	activates	gene	0.60
cancer	activates	disease	0.60
autophagy pathway	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
necroptosis	participates_in	pathway	0.60
TNF	inhibits	gene	0.60
IRAK4	inhibits	gene	0.60
TLR4	inhibits	gene	0.60
TRAF6	inhibits	gene	0.60
JAK	inhibits	gene	0.60
JNK	inhibits	gene	0.60
PI3K	inhibits	gene	0.60
PI3K-AKT-mTOR signaling	participates_in	pathway	0.60
JAK-STAT signaling	participates_in	pathway	0.60
NEMO	activates	gene	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
YY1	activates	gene	0.60
neuroinflammation	activates	disease	0.60
ROS	activates	gene	0.60
neuroinflammation	inhibits	disease	0.60

Incoming (19)

Source	Relation	Type	Str
NEMO	associated_with	protein	0.90
PER2	promotes	gene	0.88
NEMO	activates	protein	0.70
ASC	activates	gene	0.60
ATG	activates	gene	0.60
BECN1	activates	gene	0.60
BRG1	activates	gene	0.60
CCDC50	activates	gene	0.60
CLDN2	activates	gene	0.60
ERN1	activates	gene	0.60
rapamycin	targets	drug	0.60
HMGB1	inhibits	gene	0.60
ACC	inhibits	gene	0.60
metformin	targets	drug	0.60
EAAT2	activates	gene	0.60
DR3	inhibits	gene	0.60
DR3	activates	gene	0.60
CK2	regulates	gene	0.60
EAAT2	co_expressed_with	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

IKK

Understanding Entity Pages

Summary

Wiki Pages (20)

neuroinflammation

TREM2 Mechanism Hub

Neurotrophin Signaling Pathways in Neurodegeneration

nlrc5-protein

Genistein for Mild Cognitive Impairment (NCT07385937)

NF-kB Signaling Pathway in Neurodegeneration

NF-κB Signaling Pathway in Neurodegeneration

TREM2→Microglial Dysfunction→Alzheimer's Disease Causal Chain

Advanced Glycation End Products in Neurodegeneration

alpha-lipoic-acid-neurodegeneration

Neuroinflammation in Parkinson's Disease

cGAS-STING Signaling in Parkinson's Disease

TREM2 Signaling in Neurodegeneration

UBE2V1 Gene (UEV-1)

FOXO4 — Forkhead Box O4

nfkb-neurodegeneration

OTULIN-Tau Regulation Pathway

FBXO3 Protein