protein

Cytokine

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Cytokine: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1485Connections

2Hypotheses

3Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

🔬 Protein Info

Gene Symbol	Cytokine
Associated Diseases	Aging, Als, Alzheimer, Amyotrophic Lateral Sclerosis, Anxiety, Cancer
Interactions	STING, MITOCHONDRIA, DNA, MTDNA, CGAS, IL-10
KG Connections	1180 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

cbs-psp-daily-action-plan

therapeutic · 30834 words

→

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

therapeutic · 15794 words

→

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

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Clinical Management Guide for CBS/PSP

therapeutic · 15224 words

→

Progressive Supranuclear Palsy (PSP)

disease · 12907 words

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Pathway Diagram

graph TD
    Cytokine["Cytokine"] -->|"activates"| Aging["Aging"]
    style Aging fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Cytokine["Cytokine"] -->|"associated"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    style Amyotrophic_Lateral_Sclerosis fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Cytokine["Cytokine"] -->|"associated"| Als["Als"]
    style Als fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Cytokine["Cytokine"] -->|"therapeutic target"| Alzheimer["Alzheimer"]
    style Alzheimer fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Cytokine["Cytokine"] -->|"interacts"| Atherosclerosis["Atherosclerosis"]
    style Atherosclerosis fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Cytokine["Cytokine"] -->|"interacts"| Stroke["Stroke"]
    style Stroke fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Cytokine["Cytokine"] -->|"contributes to"| Neurodegeneration["Neurodegeneration"]
    style Neurodegeneration fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    IFN["IFN"] -->|"associated"| Cytokine["Cytokine"]
    style IFN fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    STING["STING"] -->|"activates"| Cytokine["Cytokine"]
    style STING fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    MITOCHONDRIA["MITOCHONDRIA"] -->|"activates"| Cytokine["Cytokine"]
    style MITOCHONDRIA fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    TDP_43["TDP-43"] -->|"associated"| Cytokine["Cytokine"]
    style TDP_43 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    ALS["ALS"] -->|"associated"| Cytokine["Cytokine"]
    style ALS fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style Cytokine fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (370)

Target	Relation	Type	Str
Microglia	activates	cell	0.70
Aging	activates	disease	0.60
Amyotrophic Lateral Sclerosis	associated_with	disease	0.60
Als	associated_with	disease	0.60
Als	regulates	disease	0.60
Alzheimer	therapeutic_target	disease	0.60
Als	therapeutic_target	disease	0.60
Atherosclerosis	interacts_with	disease	0.60
Stroke	interacts_with	disease	0.60
Neurodegeneration	contributes_to	disease	0.60
Parkinson	contributes_to	disease	0.60
Als	activates	disease	0.60
Cancer	expressed_in	disease	0.60
Autism	regulates	disease	0.60
Traumatic Brain Injury	regulates	disease	0.60
Alzheimer	regulates	disease	0.60
Aging	regulates	disease	0.60
Depression	regulates	disease	0.60
Neuroinflammation	regulates	disease	0.60
Neurodegeneration	activates	disease	0.60
Ischemia	activates	disease	0.60
Neuroinflammation	activates	disease	0.60
Neuropathy	activates	disease	0.60
Cancer	inhibits	disease	0.60
Als	inhibits	disease	0.60
Aging	biomarker_for	disease	0.60
Cancer	biomarker_for	disease	0.60
Als	biomarker_for	disease	0.60
Ferroptosis	therapeutic_target	disease	0.60
Parkinson	therapeutic_target	disease	0.60
Als	expressed_in	disease	0.60
Stroke	activates	disease	0.60
Parkinson	activates	disease	0.60
Cancer	activates	disease	0.60
Diabetes	activates	disease	0.60
Fibrosis	activates	disease	0.60
Als	contributes_to	disease	0.60
Obesity	activates	disease	0.60
Frontotemporal Dementia	therapeutic_target	disease	0.60
Dementia	therapeutic_target	disease	0.60
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.60
Alzheimer	biomarker_for	disease	0.60
Traumatic Brain Injury	inhibits	disease	0.60
Neuroinflammation	inhibits	disease	0.60
Ischemia	inhibits	disease	0.60
Senescence	regulates	disease	0.60
Alzheimer	activates	disease	0.60
Hypertension	activates	disease	0.60
Pyroptosis	activates	disease	0.60
Alzheimer	associated_with	disease	0.60

Incoming (1115)

Source	Relation	Type	Str
Astrocyte	produces	cell	0.70
IFN	associated_with	gene	0.60
STING	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
TDP-43	associated_with	gene	0.60
ALS	associated_with	gene	0.60
DNA	activates	gene	0.60
MTDNA	activates	gene	0.60
CGAS	activates	gene	0.60
E2F3	regulates	gene	0.60
E2F1	regulates	gene	0.60
E2F7	regulates	gene	0.60
E2F8	regulates	gene	0.60
E2F2	regulates	gene	0.60
DNA	regulates	gene	0.60
ROS	regulates	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
CYTOKINES	regulates	gene	0.60
BACE1	therapeutic_target	gene	0.60
REL	regulates	gene	0.60
IL-10	activates	gene	0.60
CERS2	regulates	gene	0.60
HSPG2	interacts_with	gene	0.60
IL6	inhibits	gene	0.60
CXCL1	inhibits	gene	0.60
ATF4	therapeutic_target	gene	0.60
DDIT3	therapeutic_target	gene	0.60
IRE1	therapeutic_target	gene	0.60
HSPA5	therapeutic_target	gene	0.60
RNA	therapeutic_target	gene	0.60
IL12B	inhibits	gene	0.60
OCLN	inhibits	gene	0.60
XBP1	therapeutic_target	gene	0.60
PERK	therapeutic_target	gene	0.60
CYTOKINES	inhibits	gene	0.60
IL23A	inhibits	gene	0.60
PPP1R15A	therapeutic_target	gene	0.60
CLDN5	inhibits	gene	0.60
CNO	biomarker_for	gene	0.60
PD-L1	therapeutic_target	gene	0.60
IGF2R	therapeutic_target	gene	0.60
TFEB	contributes_to	gene	0.60
MITOCHONDRIA	contributes_to	gene	0.60
GBA	contributes_to	gene	0.60
MICROGLIA	contributes_to	gene	0.60
TMEM175	contributes_to	gene	0.60
PARKINSON	contributes_to	gene	0.60
AUTOPHAGY	contributes_to	gene	0.60
CYTOKINES	contributes_to	gene	0.60
CRH	activates	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Astrocyte-Microglia Communication Rebalancing via Cytokine M	0.490	neurodegeneration	Which cell types show the most significa
Mitochondrial-Cytokine Axis Modulation	0.443	neurodegeneration	Gene expression changes in aging mouse b

Mentioning Analyses (3)

Scientific analyses that reference this entity

Neuroinflammation and microglial priming in early AD

neurodegeneration | 2026-04-04 | 7 hypotheses Top: 0.498

Neuroinflammation and microglial priming in early Alzheimer's Disease

neurodegeneration | 2026-04-04 | 0 hypotheses

Systemic immune profiling and peripheral immune contributions to neurodegenerati

neurodegeneration | 2026-04-04 | 0 hypotheses

Related Papers (4)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
IL1A enhances TNF-induced retinal ganglion cell death. [PMID:41728092]	Andersh KM, MacLean M, Howell GR, Libby	Front Aging Neurosci	2026
IL1A enhances TNF-induced retinal ganglion cell death. [PMID:38854045]	Andersh KM, MacLean M, Howell GR, Libby	bioRxiv	2024
Dietary Polyphenols Decrease Chemokine Release by Human Primary Astrocytes Respo [PMID:37765263]	Grabarczyk M, Ksiazek-Winiarek D, Glabin	Pharmaceutics	2023
Human Primary Astrocytes Differently Respond to Pro- and Anti-Inflammatory Stimu [PMID:35892669]	Szpakowski P, Ksiazek-Winiarek D, Turnia	Biomedicines	2022

Cytokine

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Parkinson's Disease

Sleep and Circadian Dysfunction in Alzheimer's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Atypical Parkinsonism

Device Therapies Comparison for CBS/PSP

Parthanatos in Neurodegeneration

calcium-dysregulation-comparison

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

PD Combination Therapy Matrix

Corticobasal Degeneration (CBD)

nhp-validation-animal-model

nimodipine-als

Neuroresilience Mechanisms and Evidence