| Gene Symbol | NCSTN |
| Aliases | NICASTRINPROTEIN |
| Chromosome | 1p31.3 |
| Protein Family | Pen-2 family (γ-secretase complex) |
| Function | Complex Assembly: Nicastrin acts as a scaffold for γ-secretase complex assembly in the ER |
| Primary Expression | Endoplasmic reticulum, Golgi apparatus, cell membrane |
| Subcellular Localization | Endoplasmic reticulum, Golgi apparatus, cell membrane |
| Molecular Weight | 79 kDa |
| Amino Acids | 709 aa |
| Exons | 21 |
| Pathways | NF-κB |
| UniProt ID | Q92673 |
| GeneCards | NCSTN |
| Human Protein Atlas | NCSTN |
| Large extracellular domain | ~100 kDa, forms the substrate docking site |
| Associated Diseases | ALS, Alzheimer, Neurodegeneration |
| Interactions | ALZHEIMER, ALZHEIMER DISEASE, AMYLOID, APH-1, APP, Aβ |
| KG Connections | 75 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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