| Gene Symbol | NLRX1 |
| Aliases | NLRX1PROTEIN |
| Chromosome | 6q16.1 |
| Protein Type | Receptor |
| Function | Upon detection of viral RNA in the cytosol, NLRX1 interacts with MAVS (Mitochondrial Antiviral Signaling Protein) to enhance downstream NF-κB and IRF activation, leading to production of type I interf |
| Primary Expression | multiple tissues, including the brain, where it is found in neurons, astrocytes, and [microglia](/cell-ty |
| Subcellular Localization | Mitochondrial outer membrane |
| Molecular Weight | ~103 kDa |
| Amino Acids | 977 aa |
| Pathways | NF-κB |
| UniProt ID | Q9NWV8 |
| NCBI Gene ID | 79671 |
| Ensembl ID | ENSG00000170873 |
| GeneCards | NLRX1 |
| Human Protein Atlas | NLRX1 |
| Associated Diseases | Parkinson |
| Interactions | MTOR, OPTN, PINK1, PRKN, PTEN, TIMM23 |
| KG Connections | 75 knowledge graph edges |
| Databases | GeneCardsHPASTRING |