gene

ATG16L1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATG16L1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

568Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

ATG16L1 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, regulates. Associated with ALS, Aging, Als. Connected to 389 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ATG16L1
Full Name	Autophagy Related 16 Like 1
Chromosome	2q37.1
Function	is a core autophagy protein essential for autophagosome formation and cellular protein quality control.
Primary Expression	neurons and glial cells throughout the brain, including the cortex, [hippocam
Amino Acids	607 aa
Pathways	Akt, Autophagy, Epigenetic, Mapk, Mtor
Ensembl ID	ENSG00000085978
GeneCards	ATG16L1
Human Protein Atlas	ATG16L1
Associated Diseases	Inflammation, Intestinal Disease, Osteoarthritis, Parkinson, Rheumatoid Arthritis, Tumor
Known Drugs/Compounds	rapamycin
Interactions	RB1CC1, GABARAP, ERN1, STAT3, IFNG, LC3
KG Connections	568 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ATG16L1["ATG16L1"] -->|"regulates"| autophagy["autophagy"]
    ATG16L1["ATG16L1"] -->|"associated"| ferroptosis["ferroptosis"]
    ATG16L1["ATG16L1"] -->|"regulates"| LC3["LC3"]
    ATG16L1["ATG16L1"] -->|"interacts"| Cancer["Cancer"]
    ATG16L1["ATG16L1"] -->|"interacts"| Als["Als"]
    ATG16L1["ATG16L1"] -->|"interacts"| Ms["Ms"]
    V_ATPase["V-ATPase"] -->|"interacts"| ATG16L1["ATG16L1"]
    ZFP36["ZFP36"] -.->|"inhibits"| ATG16L1["ATG16L1"]
    OPTN["OPTN"] -->|"interacts"| ATG16L1["ATG16L1"]
    CASP3["CASP3"] -->|"regulates"| ATG16L1["ATG16L1"]
    style ATG16L1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (332)

Target	Relation	Type	Str
Autophagy	associated_with	pathway	1.00
ATG12-ATG5 CONJUGATE	interacts_with	protein	0.95
Intestinal Epithelial Barrier Function	regulates	phenotype	0.95
autophagy	regulates	pathway	0.90
Casm	involved_in	process	0.90
intestinal epithelial cells	expressed_in	cell_type	0.90
Intestinal Disease	associated_with	disease	0.88
Crohn's Disease	risk_factor_for	disease	0.88
Inflammation	associated_with	disease	0.85
ferroptosis	associated_with	pathway	0.80
autophagy pathway	participates_in	pathway	0.80
Intestinal Epithelial Barrier	regulates	process	0.75
Als	activates	disease	0.75
Tumor	activates	disease	0.75
Cancer	regulates	disease	0.75
Inflammation	activates	disease	0.75
Tumor	associated_with	disease	0.75
Infection	activates	disease	0.75
Bacterial Infection	activates	disease	0.75
LC3	regulates	protein	0.70
CGAS	activates	gene	0.70
ATG7	associated_with	gene	0.70
UBIQUITIN	interacts_with	gene	0.70
LAMP1	activates	gene	0.70
Autophagy	regulates	pathway	0.70
Autophagy	activates	pathway	0.70
AUTOPHAGY	activates	gene	0.70
AUTOPHAGY	regulates	gene	0.70
AUTOPHAGY	associated_with	gene	0.70
Autophagy	expressed_in	pathway	0.70
UBIQUITIN	targets	protein	0.65
Cancer	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Fibrosis	regulates	disease	0.65
Glioblastoma	activates	disease	0.65
Cancer	activates	disease	0.65
Als	regulates	disease	0.65
Aging	interacts_with	disease	0.65
Parkinson	activates	disease	0.65
Ms	activates	disease	0.65
Autoimmune	inhibits	disease	0.65
Epilepsy	regulates	disease	0.65
Carcinoma	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Ms	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Cardiovascular	expressed_in	disease	0.65

Incoming (236)

Source	Relation	Type	Str
V-ATPASE	interacts_with	protein	0.93
V-ATPase	interacts_with	protein	0.90
ZFP36	inhibits	gene	0.90
STING	interacts_with	protein	0.85
ZDHHC7	modulates	gene	0.80
AUTOPHAGY	associated_with	gene	0.80
ATG5	associated_with	gene	0.70
CGAS	activates	gene	0.70
FIP200	associated_with	gene	0.70
LC3	interacts_with	gene	0.70
ATG14	associated_with	gene	0.70
LC3	associated_with	gene	0.70
CYTOKINES	activates	gene	0.70
TLR	activates	gene	0.70
INFLAMMATION	activates	gene	0.70
INFLAMMATION	associated_with	gene	0.70
AUTOPHAGY	expressed_in	gene	0.70
AUTOPHAGY	targets	phenotype	0.65
OPTN	interacts_with	gene	0.60
CASP3	regulates	gene	0.60
AKT1	regulates	gene	0.60
CALCOCO2	regulates	gene	0.60
CGAS	regulates	gene	0.60
CFTR	regulates	gene	0.60
SQSTM1	interacts_with	gene	0.60
RPS6KB1	interacts_with	gene	0.60
GRB2	interacts_with	gene	0.60
RHEB	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
EIF2A	interacts_with	gene	0.60
LRRK2	interacts_with	gene	0.60
GABARAP	interacts_with	gene	0.60
P38	interacts_with	gene	0.60
PIK3C3	interacts_with	gene	0.60
DDIT3	interacts_with	gene	0.60
IFNG	interacts_with	gene	0.60
PI3K	interacts_with	gene	0.60
TFEB	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
AMBRA1	regulates	gene	0.60
ATF6	regulates	gene	0.60
HSPA5	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
MAPK14	interacts_with	gene	0.60
MLKL	interacts_with	gene	0.60
TFE3	interacts_with	gene	0.60
BECN1	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ATG16L1

Understanding Entity Pages

Summary

Wiki Pages (21)

ATG16L1 - Autophagy Related 16 Like 1

Autophagy Mechanisms

Mitophagy Pathway in Neurodegeneration

rapamycin-tauopathy

Autophagy Failure Comparison -- AD/PD/ALS/FTD/HD

MSA Genetics and Risk Factors

Autophagy-Lysosomal Pathway in Parkinson's Disease

autophagy-lysosome-dysfunction

Autophagy-Lysosomal Pathway

Mitophagy

autophagy

Autophagy-Impaired Neurons

RIPK2 (Receptor-Interacting Serine/Threonine-Protein Kinase 2)

ATG7 Protein — Autophagy-Related Protein 7

Autophagy-Lysosome Pathway in Neurodegeneration

spermidine-neurodegeneration

casp3

CBS Autophagy-Lysosomal Pathway Dysfunction

BECN1 Protein (Beclin-1)

ATG14 Protein