| Gene Symbol | NNMT |
| Full Name | Nicotinamide N-methyltransferase |
| Aliases | NNMTPROTEIN |
| Chromosome | 11q23.2 |
| Protein Type | Enzyme |
| Function | NNMT catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (SAM) to nicotinamide, producing N-methylnicotinamide (MNAM) and S-adenosyl-L-homocysteine (SAH). |
| Primary Expression | various brain regions: - Cerebral cortex - Hippocampus - Substantia nigra - [Cerebellum](/brain |
| Subcellular Localization | </b></td><td>Cytoplasm</td></tr> |
| Molecular Weight | 30 kDa |
| UniProt ID | P40261 |
| NCBI Gene ID | 4837 |
| Ensembl ID | ENSG00000166741 |
| GeneCards | NNMT |
| Human Protein Atlas | NNMT |
| SAM-binding domain | Conserved methyltransferase fold |
| Associated Diseases | Alzheimer's_disease, Huntington's_disease, mitochondrial_dysfunction, neurodegenerative_disorders, neuroinflammation, Parkinson's_disease |
| Interactions | AKT, DNA_methyltransferases, ERBB4, histone_methyltransferases, NAD, PI3K |
| KG Connections | 43 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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