protein 1,100 words KG: NR1D1PROTEIN 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

REV-ERBα Protein

🔬 Protein Info
Gene SymbolREV
Full NameERBα Protein — Nuclear Receptor Subfamily 1 Group D Member 1
AliasesNR1D1PROTEIN
Protein FamilyNuclear receptor family, REV-ERB subfamily
Subcellular Localizationsignal - **Ligand-binding domain (LBD)**: Binds heme as an endogenous ligand; co
Molecular Weight~51 kDa
Pathwayscircadian regulation
UniProt IDQ9UGL9
GeneCardsREV
Human Protein AtlasREV
Associated DiseasesALS
Known Drugs/Compoundslithium
InteractionsHDAC3, BMAL1, CLOCK
KG Connections24 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (12)

Temporal Decoupling via Circadian Clock Reset
Score: 0.52
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.48
HDAC3-Selective Inhibition for Clock Reset
Score: 0.46
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.56
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68

Related Analyses (9)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived

Related Experiments (2)

REV-ERB pharmacological activation blocks SD effects
validation · proposed · Score: 0.90
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
Wnt/β-Catenin Signaling Pathway in Neurodegeneration
mechanism · Pages share 3 hypotheses
WNK1-Bilirubin Signaling in Neuroinflammation and Neuro
mechanism · Pages share 3 hypotheses
vip-vasoactive-intestinal-peptide-signaling-neurodegene
mechanism · Pages share 3 hypotheses
VEGF Signaling and Cerebral Angiogenesis in Neurodegene
mechanism · Pages share 3 hypotheses