| Gene Symbol | NR4A2PROTEIN |
| Protein Type | Receptor |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Subcellular Localization | </th><td>Nucleus</td></tr> |
| Amino Acids | 4477 aa |
| GeneCards | NR4A2PROTEIN |
| Human Protein Atlas | NR4A2PROTEIN |
| N-terminal Domain | Contains the activation function-1 (AF-1) region for transcriptional activation |
| DNA-Binding Domain (DBD) | Two C4-type zinc finger motifs that bind to NGFI-B response elements (NBRE) |
| Hinge Region | Flexible linker connecting DBD to LBD |
| Ligand-Binding Domain (LBD) | Contains the AF-2 activation function; binds to Nur response elements (NRE) as a monomer or heterodimer |
| Dopaminergic Development | Essential for tyrosine hydroxylase (TH) and dopamine transporter (DAT) expression |
| Neuronal Survival | Promotes anti-apoptotic gene expression |
| Neuroinflammation | Represses microglial activation |
| Metabolic Regulation | Modulates glucose and lipid metabolism |
| Associated Diseases | neurodegeneration |
| Interactions | APOPTOSIS, App, CANCER, CCL2, CD8, CX3CR1 |
| KG Connections | 102 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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