gene

CD8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CD8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1158Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

CD8 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, inhibits. Associated with ALS, Aging, Als. Connected to 614 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CD8A, CD8B
Aliases	CD8
Chromosome	2p11.2 (CD8A), 2p11.2 (CD8B)
Protein Family	Immunoglobulin superfamily
Protein Type	Receptor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	~25-32 kDa (heterodimer)
Pathways	Adaptive Immunity, Amyloid, Apoptosis, Autophagy, Cholesterol
UniProt ID	P01732 (CD8A), P10966 (CD8B)
NCBI Gene ID	931 (CD8A), 915 (CD8B)
Gene Name	CD8 Alpha Chain, CD8 Beta Chain
Ig-like V-type domain	MHC class I binding
Hinge region	Flexibility for optimal interaction
Target	Approach
CD8+ T cell depletion	Anti-CD8 antibodies
Associated Diseases	ALS, Aging, Alzheimer, Amyotrophic Lateral Sclerosis, Arthritis
Known Drugs/Compounds	dimethyl fumarate
Interactions	PDGFRB, ANGPT1, IRF1, CIITA, RIPK1, RIPK3
KG Connections	1156 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CD8 — AlphaFold P01732 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    CD8(["CD8"])
    Cancer["Cancer"]
    Tumor["Tumor"]
    Als["Als"]
    Inflammation["Inflammation"]
    GENES(["GENES"])
    CANCER(["CANCER"])
    INFLAMMATION(["INFLAMMATION"])
    Lung_Cancer["Lung Cancer"]
    STING(["STING"])
    Checkpoint_Inhibitor["Checkpoint Inhibitor"]
    Immunotherapy["Immunotherapy"]

    CD8 -->|"activates"| Cancer
    CD8 -->|"activates"| Tumor
    CD8 -->|"therapeutic target"| Cancer
    CD8 -->|"activates"| Als
    CD8 -.->|"inhibits"| Cancer
    CD8 -->|"activates"| Inflammation
    GENES -->|"activates"| CD8
    CANCER -->|"activates"| CD8
    CANCER -->|"therapeutic target"| CD8
    INFLAMMATION -->|"activates"| CD8
    CD8 -.->|"inhibits"| Tumor
    CD8 -->|"activates"| Lung_Cancer
    CD8 -->|"activates"| STING
    CD8 -->|"activates"| Checkpoint_Inhibitor
    CD8 -->|"therapeutic target"| Immunotherapy

    style CD8 fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (805)

Target	Relation	Type	Str
Cancer	activates	disease	1.00
Tumor	activates	disease	1.00
Cancer	therapeutic_target	disease	1.00
Als	activates	disease	1.00
Cancer	inhibits	disease	1.00
Inflammation	activates	disease	1.00
Tumor	inhibits	disease	0.95
Lung Cancer	activates	disease	0.95
T CELLS	interacts_with	cell_type	0.95
T cells	associated_with	cell_type	0.90
STING	activates	gene	0.90
Checkpoint Inhibitor	activates	pathway	0.90
Immunotherapy	therapeutic_target	pathway	0.90
Tumor Microenvironment	activates	pathway	0.90
Immune Checkpoint	activates	pathway	0.90
Als	expressed_in	disease	0.85
Carcinoma	activates	disease	0.85
Als	inhibits	disease	0.85
Als	therapeutic_target	disease	0.85
Tumor	associated_with	disease	0.85
Tumor	regulates	disease	0.85
Cancer	regulates	disease	0.85
Carcinoma	therapeutic_target	disease	0.85
Tumor	therapeutic_target	disease	0.85
T CELLS	activates	cell_type	0.80
T cells	activates	cell_type	0.80
T cells	expressed_in	cell_type	0.80
Glioblastoma	biomarker_for	disease	0.80
T cells	modulates	cell_type	0.80
oxidative stress response	participates_in	pathway	0.80
CD4	associated_with	gene	0.80
MYC	activates	gene	0.80
Phagocytosis	activates	pathway	0.80
Apoptosis	activates	pathway	0.80
Autophagy	activates	pathway	0.80
Immune Response	inhibits	pathway	0.80
MICROGLIA	activates	gene	0.80
IFN	activates	gene	0.80
Immunotherapy	activates	pathway	0.80
Cancer	expressed_in	disease	0.75
Neurodegeneration	activates	disease	0.75
Aging	activates	disease	0.75
Parkinson	expressed_in	disease	0.75
Inflammation	expressed_in	disease	0.75
Inflammation	associated_with	disease	0.75
Aging	inhibits	disease	0.75
Inflammation	therapeutic_target	disease	0.75
Carcinoma	expressed_in	disease	0.75
Carcinoma	inhibits	disease	0.75
Als	regulates	disease	0.75

Incoming (353)

Source	Relation	Type	Str
GENES	activates	gene	1.00
CANCER	activates	gene	1.00
CANCER	therapeutic_target	gene	1.00
INFLAMMATION	activates	gene	1.00
APOPTOSIS	activates	gene	0.90
CD19	associated_with	gene	0.80
CCL5	activates	gene	0.80
STING	activates	gene	0.80
GENES	associated_with	gene	0.80
CANCER	inhibits	gene	0.80
GSDME	activates	gene	0.70
CXCL10	activates	gene	0.70
CD4	inhibits	gene	0.70
TREX1	activates	gene	0.70
STAT3	activates	gene	0.70
CD4	therapeutic_target	gene	0.70
EGFR	activates	gene	0.70
CD40	activates	gene	0.70
AGING	inhibits	gene	0.70
CANCER	regulates	gene	0.70
CANCER	expressed_in	gene	0.70
PHAGOCYTOSIS	activates	gene	0.70
APOPTOSIS	inhibits	gene	0.70
PARKINSON	expressed_in	gene	0.70
INFLAMMATION	expressed_in	gene	0.70
CYTOKINES	activates	gene	0.70
NEURODEGENERATION	activates	gene	0.70
AUTOPHAGY	activates	gene	0.70
PARKINSON'S DISEASE	expressed_in	gene	0.70
MHC-I	inhibits	gene	0.70
beta_hydroxybutyrate	regulates	drug	0.64
glycogen_metabolism	regulates	pathway	0.64
NPM1	activates	gene	0.60
NLRC5	activates	gene	0.60
JUN	activates	gene	0.60
MAF	inhibits	gene	0.60
SPP1	associated_with	gene	0.60
STING	associated_with	gene	0.60
PDGFRB	activates	gene	0.60
IRF1	activates	gene	0.60
CIITA	activates	gene	0.60
CD4	associated_with	gene	0.60
STAR	expressed_in	gene	0.60
RIPK3	activates	gene	0.60
RIPK1	activates	gene	0.60
PRDM1	inhibits	gene	0.60
CAMK4	associated_with	gene	0.60
CD4	expressed_in	gene	0.60
GPX4	inhibits	gene	0.60
LDLR	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Do CXCL10-recruited CD8+ T cells provide neuroprotection or cause damage in agin

neuroimmunology | 2026-04-15 | 1 hypotheses Top: 0.514

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CD8

Understanding Entity Pages

Summary

Wiki Pages (21)

CD8 Gene

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

NPM1 Gene

neuroinflammation

nlrc5-protein

rapamycin-tauopathy

Frontotemporal Dementia

Neuroinflammation Across AD, PD, ALS, FTD, and HD

neurovascular-dysfunction

RASGRP1 Gene

Orexin Neurons

Neuroinflammation in Amyotrophic Lateral Sclerosis

msa-pathophysiology-disease-mechanisms

Blood-Brain Barrier Breakdown in Neurodegeneration

Neuroinflammation in Parkinson's Disease

blood-brain-barrier-endothelial-cells

Remyelination in Neurodegeneration

Viral Vector Delivery Investment Landscape for Neurodegeneration

aav-gene-therapy-neurodegeneration

Adaptive Immunity in Neurodegeneration