protein 1,114 words KG: P2X7RECEPTOR 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

P2X7 Receptor Protein

🔬 Protein Info
Gene SymbolP2X7RECEPTOR
Full NameP2X7 Receptor
Protein FamilyP2X purinergic receptor family
Protein TypeChannel
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionmicroglia and immune cells and is a therapeutic target for neuroinflammatory diseases
Subcellular LocalizationPlasma membrane, lipid rafts
Molecular Weight66 kDa (monomer)
Amino Acids200 aa
UniProt IDQ99572
GeneCardsP2X7RECEPTOR
Human Protein AtlasP2X7RECEPTOR
Protein NameP2X7 Receptor
GeneP2RX7
PDB Structures5U1L, 6U9V, 7KB5
Associated DiseasesAlzheimer'S Disease, Neurodegenerative Diseases, Pain, disease
InteractionsP2X7, NLRP3, IL-6, PHAGOCYTOSIS, P2RX7, adnp
KG Connections56 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (9)

Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.62
Purinergic Signaling Polarization Control
Score: 0.55
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Microglial Purinergic Reprogramming
Score: 0.48
Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.48

Related Analyses (9)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived

Related Experiments (4)

P2rx7 congenic mouse model insulin tolerance testing
validation · proposed · Score: 0.90
P2rx7 congenic mouse model glucose tolerance testing
validation · proposed · Score: 0.90
Gap Junction Dysfunction Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
Purinergic Signaling Dysfunction Validation in Parkinson's D
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in