protein 1,879 words KG: PALB2PROTEIN 2026-03-26
kind:proteinsection:proteinsstate:published
Contents

PALB2 Protein - Partner and Localizer of BRCA2

🔬 Protein Info
Gene SymbolPALB2
Full NamePartner And Localizer of BRCA2
AliasesPALB2PROTEIN
Chromosome16p12.2
Functionencodes a critical DNA repair protein that serves as a central hub in the Fanconi anemia pathway and homologous recombination repair.
Subcellular Localization</b></td><td>Nucleus, chromatin</td></tr> [@wang2017]
Molecular Weight130 kDa
Amino Acids1186 aa
Ensembl IDENSG00000083093
GeneCardsPALB2
Human Protein AtlasPALB2
Associated DiseasesCancer
InteractionsUBIQUITIN, DNA, RAD18, BRCA1
KG Connections57 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (6)

Purinergic Signaling Polarization Control
Score: 0.55
Mechanosensitive Ion Channel Reprogramming
Score: 0.51
Lipid Droplet Dynamics as Phenotype Switches
Score: 0.46
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42

Related Analyses (7)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
ALS Therapeutic Landscape — Programs by Phase and Modal
disease · Pages share 3 hypotheses
Wnt/β-Catenin Signaling Pathway in Neurodegeneration
mechanism · Pages share 3 hypotheses
WNK1-Bilirubin Signaling in Neuroinflammation and Neuro
mechanism · Pages share 3 hypotheses
vip-vasoactive-intestinal-peptide-signaling-neurodegene
mechanism · Pages share 3 hypotheses