| Gene Symbol | PPP1R15A |
| Aliases | GADD34 |
| Chromosome | 19q13 |
| Protein Type | Gene |
| Function | encodes a stress-inducible scaffold that recruits catalytic PP1 phosphatase to phospho-eIF2alpha substrates. |
| Pathways | Blood-Brain Barrier, Er Stress |
| GeneCards | PPP1R15A |
| Human Protein Atlas | PPP1R15A |
| N-terminal domain (1-300 aa) | Contains the PP1-binding motif and targets the complex to the ER membrane |
| C-terminal domain (300-674 aa) | Regulatory region with multiple phosphorylation sites |
| RVxF motif | Critical for PP1 binding specificity |
| Associated Diseases | neurodegeneration |
| Interactions | AND, ATF4, CLDN5, CXCL1, CXCL2, CYTOKINES |
| KG Connections | 63 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!