gene

CXCL1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CXCL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

468Connections

1Hypotheses

2Analyses

50Outgoing

50Incoming

Summary

C-X-C motif chemokine ligand 1 (GROα) - pro-inflammatory chemokine involved in neuroinflammation, glial activation, and neurodegenerative disease pathogenesis.

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🧬 Gene Info

Gene Symbol	CXCL1
Aliases	C-X-C motif chemokine ligand 1 (GROα)
Protein Type	Receptor
Primary Expression	blood-brain barrier
Amino Acids	107 aa
Pathways	Chemoresistance, Cholesterol, Tnf Signaling, Toll-Like Receptor, Tumor Microenvironment
Ensembl ID	ENSG00000163425
GeneCards	CXCL1
Human Protein Atlas	CXCL1
Associated Diseases	Alzheimer, Inflammation, Ms, Neuroinflammation, Pancreatic Cancer, Rheumatoid Arthritis
Known Drugs/Compounds	rapamycin
Interactions	CLDN5, OCLN, IL23A, CXCL10, MMP12, CXCL2
KG Connections	468 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CXCL1["CXCL1"]
    CXCL1 -->|"target for"| Ms["Ms"]
    CXCL1 -->|"target for"| Als["Als"]
    CXCL1 -->|"target for"| Atherosclerosis["Atherosclerosis"]
    CXCL1 -->|"target for"| Cardiovascular["Cardiovascular"]
    CXCL1 -->|"inhibits"| Inflammation["Inflammation"]
    CXCL1 -->|"expressed in"| Tumor["Tumor"]
    CXCL1 -->|"activates"| Alzheimer["Alzheimer"]
    CXCL1 -->|"activates"| Neuroinflammation["Neuroinflammation"]
    CXCL2["CXCL2"] -->|"inhibits"| CXCL1
    IL6["IL6"] -->|"inhibits"| CXCL1
    ATF4["ATF4"] -->|"target for"| CXCL1
    PPP1R15A["PPP1R15A"] -->|"target for"| CXCL1
    IL12B["IL12B"] -->|"inhibits"| CXCL1
    XBP1["XBP1"] -->|"target for"| CXCL1
    IL1B["IL1B"] -->|"regulates"| CXCL1
    TLR2["TLR2"] -->|"regulates"| CXCL1
    DDIT3["DDIT3"] -->|"target for"| CXCL1
    CLDN5["CLDN5"] -->|"inhibits"| CXCL1

Outgoing (301)

Target	Relation	Type	Str
Inflammation	activates	disease	1.00
Als	activates	disease	0.95
Cancer	activates	disease	0.85
Nf-Κb	activates	pathway	0.80
Tumor	expressed_in	disease	0.75
Neuroinflammation	activates	disease	0.75
Inflammation	associated_with	disease	0.75
Tumor	regulates	disease	0.75
Carcinoma	regulates	disease	0.75
Infection	activates	disease	0.75
TNF	activates	gene	0.70
CANCER	activates	gene	0.70
Mapk	activates	pathway	0.70
Inflammasome	activates	pathway	0.70
Ms	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Atherosclerosis	therapeutic_target	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Inflammation	inhibits	disease	0.65
Ms	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Alzheimer	activates	disease	0.65
Ms	activates	disease	0.65
Atherosclerosis	inhibits	disease	0.65
Als	inhibits	disease	0.65
Cardiac	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
ALS	activates	disease	0.65
ALS	inhibits	disease	0.65
Cardiovascular	inhibits	disease	0.65
Neurodegeneration	activates	disease	0.65
Cancer	regulates	disease	0.65
Aging	inhibits	disease	0.65
Pancreatic Cancer	associated_with	disease	0.65
Cardiovascular	regulates	disease	0.65
Als	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Pancreatic Cancer	activates	disease	0.65
Depression	activates	disease	0.65
Depression	treats	disease	0.65
Neuroinflammation	causes	disease	0.65
Inflammation	causes	disease	0.65
Sepsis	causes	disease	0.65
Alzheimer	associated_with	disease	0.65
Rheumatoid Arthritis	associated_with	disease	0.65
Senescence	associated_with	disease	0.65
Sepsis	therapeutic_target	disease	0.65
Cancer	inhibits	disease	0.65

Incoming (167)

Source	Relation	Type	Str
Astrocytes	product_of	cell_type	0.90
INFLAMMATION	activates	gene	0.90
Dolutegravir	upregulates	drug	0.87
DTG	upregulates	drug	0.85
AKT	upregulates	gene	0.80
Endoplasmic Reticulum Stress	upregulates	process	0.80
NF-ΚB	activates	gene	0.80
CYTOKINES	activates	gene	0.80
IL-6	activates	gene	0.80
TNF	regulates	gene	0.70
PI3K	activates	gene	0.70
TNF-Α	activates	gene	0.70
CANCER	activates	gene	0.70
CXCL2	inhibits	gene	0.60
IL6	inhibits	gene	0.60
ATF4	therapeutic_target	gene	0.60
PPP1R15A	therapeutic_target	gene	0.60
IL12B	inhibits	gene	0.60
XBP1	therapeutic_target	gene	0.60
IL1B	regulates	gene	0.60
TLR2	regulates	gene	0.60
DDIT3	therapeutic_target	gene	0.60
CLDN5	inhibits	gene	0.60
IL23A	inhibits	gene	0.60
OCLN	inhibits	gene	0.60
CXCL10	inhibits	gene	0.60
MMP12	inhibits	gene	0.60
CHIT1	therapeutic_target	gene	0.60
JUN	regulates	gene	0.60
ATF4	activates	gene	0.60
AXL	therapeutic_target	gene	0.60
CXCL8	regulates	gene	0.60
ICAM1	associated_with	gene	0.60
CXCL8	expressed_in	gene	0.60
XBP1	activates	gene	0.60
HSPA5	activates	gene	0.60
PERK	activates	gene	0.60
PPP1R15A	activates	gene	0.60
DDIT3	activates	gene	0.60
IRE1	activates	gene	0.60
MMP9	regulates	gene	0.60
AXL	inhibits	gene	0.60
GATA2	activates	gene	0.60
IL6	associated_with	gene	0.60
ANG	associated_with	gene	0.60
CXCL8	associated_with	gene	0.60
VEGF	expressed_in	gene	0.60
TNFR2	regulates	gene	0.60
TP53	inhibits	gene	0.60
APOE	regulates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
White Matter Oligodendrocyte Protection via CXCL10 Inhibitio	0.480	neurodegeneration	Gene expression changes in aging mouse b

Mentioning Analyses (2)

Scientific analyses that reference this entity

Does CXCL10 inhibition compromise CNS immune surveillance during chronic treatme

neuroimmunology | 2026-04-11 | 0 hypotheses

Systemic immune profiling and peripheral immune contributions to neurodegenerati

neurodegeneration | 2026-04-04 | 0 hypotheses

Related Papers (12)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
METTL3/CXCL10 axis contributes to renal fibrosis by promoting the apoptosis of t [PMID:41138934]	Sun Y, Ren Z, Ge J, Zhang W, Shao F et a	Biochim Biophys Acta Mol Basis	2026
IL-25-ILC2-IL-13 axis improves traumatic brain injury by mediating CXCL-10-depen [PMID:41527095]	Peng M, Shu D, Chen Z, Yang Z, Zhang M e	J Neuroinflammation	2026
Oligodendrocyte transcription factor 2 orchestrates glioblastoma immune evasion [PMID:41591814]	Zhang X, Xue J, Zhao C, Zeng C, Zhong J	J Clin Invest	2026
Indole-3-propionic acid inhibits astrocyte inflammation and promotes motor funct [PMID:41663028]	Yu D, Kang J, Jiang W, Zhang C, Zhao X e	Neuropharmacology	2026
Cobrotoxin mitigates neuroinflammation and cognitive impairment by suppressing C [PMID:41671614]	Li Z, Tan B, Dong K, Yu X, Zhang SW et a	Biochem Pharmacol	2026
Peripheral macrophages and T-cells accumulate in the degenerating optic tract af [PMID:41740873]	Main BS, Villapol S, Buenaventura RG, Ha	Brain Behav Immun	2026
Melanoma cell inoculation improves cognitive impairment in the 5xFAD mouse model [PMID:41760781]	Bruna-Jara B, More J, Lobos P, Ponce DP,	Scientific reports	2026
Chemokine-defined macrophage niches establish spatial organization of tumor immu [PMID:41872505]	Ghosh S, Li X, Rawat K, Dighal A, Kalino	Nat Immunol	2026
Multi-omics analysis and experimental validation reveal the IRF7-CXCL10 axis as [PMID:41941036]	Lai Y, Lin P, Zhang K, Hong W, Zheng M e	Cell Biol Toxicol	2026
Primary Infection with Cystoisospora suis Modulates Systemic Immunity and the Gu [PMID:41942044]	Ye X, Huang YJ, Deng XL, He ZY, Tan JJ e	Int J Parasitol	2026
Agonists for cytosolic bacterial receptor ALPK1 induce antitumour immunity. [PMID:41372408]	Tian X, Liu J, Li Y, Wang Y, Luo Y, He H	Nature	2026
HTLV1-associated myelopathy as a translational model of progressive neurodegener [PMID:41926707]	da Silva MTT, Araujo AQC	Brain : a journal of neurology	2026

CXCL1

Understanding Entity Pages

Summary

Wiki Pages (21)

CXCL1

neuroinflammation

Astrocyte Reactivity Mechanism

GBA1→GCase→Lysosome→PD Causal Chain

Cellular Senescence in Neurodegeneration

NF-κB Signaling Pathway in Neurodegeneration

cGAS-STING Signaling in Parkinson's Disease

Remyelination in Neurodegeneration

SERPINA3 Gene — Alpha-1 Antichymotrypsin in Neurodegeneration

Cellular Senescence in Neurodegeneration

Microglia Activation Mechanism

Neuroinflammation in Alzheimer's Disease

Neuroinflammation in Neurodegeneration

Astrocyte Senescence Pathway in Neurodegeneration

Inflammaging in Neurodegeneration

Senolytic Therapies for Parkinson's Disease

peripheral-immune-infiltration

Cellular Senescence Hypothesis in Parkinson's Disease

Cellular Senescence in Corticobasal Syndrome

S100 Protein Signaling Pathway in Neurodegeneration

Chemokine Signaling Pathway in Neurodegeneration

Pathway Diagram

Outgoing (301)

Incoming (167)

Targeting Hypotheses (1)

Mentioning Analyses (2)

Does CXCL10 inhibition compromise CNS immune surveillance during chronic treatme

Systemic immune profiling and peripheral immune contributions to neurodegenerati

Related Papers (12)