| Gene Symbol | PPT1 |
| Aliases | Page for PPT1 Gene, Palmitoyl-Protein Thioesterase 1 |
| Chromosome | 1p34.2 |
| Protein Family | Palmitoyl-protein thioesterase family |
| Protein Type | Enzyme |
| Function | Depalmitoylation of proteins |
| Primary Expression | neurons and glia
- Cellular Localization: Lysosomal lumen
- Developmental Expression: High during fetal development and e |
| Subcellular Localization | the lysosomal lumen, where it functions optimally at acidic pH (pH 4.5-5.0). The enzyme is synthesized in the endoplasmi |
| Molecular Weight | ~37 kDa |
| Amino Acids | 306 aa |
| Exons | 9 |
| UniProt ID | O00787 |
| NCBI Gene ID | 5538 |
| Ensembl ID | ENSG00000131238 |
| OMIM | 256730 |
| GeneCards | PPT1 |
| Human Protein Atlas | PPT1 |
| Associated Diseases | neurodegeneration |
| Interactions | TNF, SELF-DNA, ENDOSOMES, IFN, FERROPTOSIS, AUTOPHAGY |
| KG Connections | 21 knowledge graph edges |
| Databases | GeneCardsHPASTRING |