Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ENDOSOMES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
ENDOSOMES is a concept in neurodegeneration research. Key relationships include: activates, interacts with, expressed in. Associated with ALS, Aging, Als. Connected to 253 entities in the SciDEX knowledge graph.
| Name | ENDOSOMES |
| Key Genes/Proteins | C9ORF72, EGF |
| Related Diseases | Ataxia, Als, ALS, Neurodegeneration, Ms |
Knowledge base pages for this entity
graph TD
ENDOSOMES["ENDOSOMES"]
ENDOSOMES -->|"expressed in"| Neurodegeneration["Neurodegeneration"]
ENDOSOMES -->|"expressed in"| Als["Als"]
ENDOSOMES -->|"expressed in"| Ms["Ms"]
ENDOSOMES -->|"expressed in"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
ENDOSOMES -->|"expressed in"| Dementia["Dementia"]
ENDOSOMES -->|"activates"| Tumor["Tumor"]
ENDOSOMES -->|"regulates"| Aging["Aging"]
C9ORF72["C9ORF72"] -->|"binds"| ENDOSOMES
ATM["ATM"] -->|"expressed in"| ENDOSOMES
NEURODEGENERATION["NEURODEGENERATION"] -->|"expressed in"| ENDOSOMES
MOTOR_NEURONS["MOTOR NEURONS"] -->|"interacts"| ENDOSOMES
VESICLE_TRAFFICKING["VESICLE TRAFFICKING"] -->|"interacts"| ENDOSOMES
LYSOSOMAL_BIOGENESIS["LYSOSOMAL BIOGENESIS"] -->|"interacts"| ENDOSOMES
C9ORF72_REPEAT_EXPANSION["C9ORF72 REPEAT EXPANSION"] -->|"expressed in"| ENDOSOMES
CHMP2B["CHMP2B"] -->|"expressed in"| ENDOSOMES
OPTN["OPTN"] -->|"expressed in"| ENDOSOMES| Target | Relation | Type | Str |
|---|---|---|---|
| Ataxia | associated_with | disease | 0.75 |
| Als | interacts_with | disease | 0.75 |
| ALS | causes | disease | 0.75 |
| EGF | activates | gene | 0.70 |
| Neurodegeneration | expressed_in | disease | 0.65 |
| Als | expressed_in | disease | 0.65 |
| Ms | expressed_in | disease | 0.65 |
| Amyotrophic Lateral Sclerosis | expressed_in | disease | 0.65 |
| Dementia | expressed_in | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Ms | interacts_with | disease | 0.65 |
| Aging | regulates | disease | 0.65 |
| Ms | regulates | disease | 0.65 |
| Atherosclerosis | regulates | disease | 0.65 |
| Cancer | associated_with | disease | 0.65 |
| Alzheimer | expressed_in | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Alzheimer | inhibits | disease | 0.65 |
| Als | inhibits | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| Alzheimer | activates | disease | 0.65 |
| Cancer | inhibits | disease | 0.65 |
| Tumor | inhibits | disease | 0.65 |
| Alzheimer | regulates | disease | 0.65 |
| Glioblastoma | inhibits | disease | 0.65 |
| Parkinson | interacts_with | disease | 0.65 |
| Alzheimer | interacts_with | disease | 0.65 |
| ALS | interacts_with | disease | 0.65 |
| Cancer | interacts_with | disease | 0.65 |
| ALS | activates | disease | 0.65 |
| Frontotemporal Dementia | causes | disease | 0.65 |
| Dementia | causes | disease | 0.65 |
| Amyotrophic Lateral Sclerosis | causes | disease | 0.65 |
| Neurodegeneration | causes | disease | 0.65 |
| Als | causes | disease | 0.65 |
| Neurodegeneration | implicated_in | disease | 0.65 |
| Alzheimer | contributes_to | disease | 0.65 |
| Neurodegeneration | regulates | disease | 0.65 |
| Dementia | regulates | disease | 0.65 |
| Amyotrophic Lateral Sclerosis | regulates | disease | 0.65 |
| Ftd | causes | disease | 0.65 |
| Ms | causes | disease | 0.65 |
| Ftd | regulates | disease | 0.65 |
| Frontotemporal Dementia | regulates | disease | 0.65 |
| Neuroinflammation | inhibits | disease | 0.65 |
| Neurodegeneration | associated_with | disease | 0.65 |
| Source | Relation | Type | Str |
|---|---|---|---|
| C9ORF72 | binds | gene | 0.90 |
| C9ORF72 | interacts_with | gene | 0.74 |
| NEURODEGENERATION | expressed_in | gene | 0.60 |
| MOTOR NEURONS | interacts_with | gene | 0.60 |
| VESICLE TRAFFICKING | interacts_with | gene | 0.60 |
| LYSOSOMAL BIOGENESIS | interacts_with | gene | 0.60 |
| C9ORF72 REPEAT EXPANSION | expressed_in | gene | 0.60 |
| CHMP2B | expressed_in | gene | 0.60 |
| OPTN | expressed_in | gene | 0.60 |
| EXOSOMES | associated_with | gene | 0.60 |
| SYNAPTOPHYSIN | activates | gene | 0.60 |
| ATG | activates | gene | 0.60 |
| MAP1LC3 | activates | gene | 0.60 |
| MTOR | activates | gene | 0.60 |
| DMSO | activates | gene | 0.60 |
| LYSOSOMAL BIOGENESIS | activates | gene | 0.60 |
| AKT | activates | gene | 0.60 |
| EGF | activates | gene | 0.60 |
| RAB7 | interacts_with | gene | 0.60 |
| MTOR | interacts_with | gene | 0.60 |
| EGFR | interacts_with | gene | 0.60 |
| UBIQUITIN | interacts_with | gene | 0.60 |
| NBR1 | interacts_with | gene | 0.60 |
| ALZHEIMER'S DISEASE | expressed_in | gene | 0.60 |
| APP | expressed_in | gene | 0.60 |
| OGT | activates | gene | 0.60 |
| RAC1 | inhibits | gene | 0.60 |
| ALZHEIMER'S DISEASE | inhibits | gene | 0.60 |
| AMYLOID-BETA | inhibits | gene | 0.60 |
| LAMP1 | inhibits | gene | 0.60 |
| RHOA | inhibits | gene | 0.60 |
| APP | inhibits | gene | 0.60 |
| ALZHEIMER'S DISEASE | associated_with | gene | 0.60 |
| LDLR | associated_with | gene | 0.60 |
| SORL1 | interacts_with | gene | 0.60 |
| APP | interacts_with | gene | 0.60 |
| LRP10 | activates | gene | 0.60 |
| ALZHEIMER'S DISEASE | activates | gene | 0.60 |
| APP | activates | gene | 0.60 |
| SRC | inhibits | gene | 0.60 |
| PI3K | inhibits | gene | 0.60 |
| IDO1 | inhibits | gene | 0.60 |
| APOE3 | regulates | gene | 0.60 |
| LRP1 | regulates | gene | 0.60 |
| ALZHEIMER'S DISEASE | regulates | gene | 0.60 |
| APOE4 | regulates | gene | 0.60 |
| CD44 | inhibits | gene | 0.60 |
| RAB7 | contributes_to | gene | 0.60 |
| RAB7A | contributes_to | gene | 0.60 |
| RAB7A | interacts_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||