protein 1,699 words KG: PTBP1PROTEIN 2026-03-27
kind:proteinsection:proteinsstate:published
Contents

PTBP1 Protein — Polypyrimidine Tract Binding Protein 1

🔬 Protein Info
Gene SymbolPTBP1
Full NamePolypyrimidine Tract Binding Protein 1
AliasesPTBP1PROTEIN
Chromosome19p13.3
Protein FamilyhnRNP family, RNA recognition motif (RRM) proteins
Functionis a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) family of RNA-binding proteins.
Primary Expressionneural progenitor cells and declines as neurons differentiate
Subcellular LocalizationNucleus, Cytoplasm (shuttles between)
Molecular Weight~57 kDa (531 amino acids)
Amino Acids531 aa
Exons15
PathwaysAutophagy, Epigenetic, Glycolysis, Innate Immunity, Stem Cell
UniProt IDP26512
Ensembl IDENSG00000064102
GeneCardsPTBP1
Human Protein AtlasPTBP1
Associated DiseasesAls
InteractionsCALCOCO2, EGR1, NDP52, P38, SLC7A11, GPX4
KG Connections103 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (9)

Stathmin-2 Splice Switching to Prevent Axonal Degeneration A
Score: 0.66
Biorhythmic Interference via Controlled Sleep Oscillations
Score: 0.41
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Cryptic Exon Silencing Restoration
Score: 0.46
Cross-Seeding Prevention Strategy
Score: 0.45

Related Analyses (7)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · completed

Related Experiments (13)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

Key Papers (1)

Assessment of the Spatial Distribution of Moisture Content in Granular
Sensors (Basel, Switzerland) 2024

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in