protein 795 words KG: RILPPROTEIN
Contents

Rab Interacting Lysosomal Protein Protein

🔬 Protein Info
Gene SymbolRILPPROTEIN
Functionis an important component in the neurobiology of neurodegenerative diseases.
Subcellular Localization</th><td>Lysosomes, Late Endosomes</td></tr>
Molecular Weight48 kDa
Amino Acids150 aa
GeneCardsRILPPROTEIN
Human Protein AtlasRILPPROTEIN
Rab-binding regionInteracts with active GTP-bound Rab7
Dimerization interfaceFacilitates RILP homodimer formation
Coiled-coil motifsMediates protein-protein interactions
Dynein-dynactin recruitment siteBinds dynein light intermediate chain
Dimerization domainStabilizes RILP dimers
Regulatory regionContains phosphorylation sites
Associated DiseasesAls
Known Drugs/Compoundsrapamycin
InteractionsALZHEIMER'S DISEASE, AMPK, AND, ATG5, ATM, ATP6V1G1
KG Connections93 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (9)

APOE-Dependent Autophagy Restoration
Score: 0.89
Lysosomal Enzyme Trafficking Correction
Score: 0.71
Lysosomal Calcium Channel Modulation Therapy
Score: 0.70
Lysosomal Positioning Dynamics Modulation
Score: 0.69
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Lysosomal Membrane Repair Enhancement
Score: 0.54

Related Analyses (7)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed

Related Experiments (3)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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