| Gene Symbol | RPN2PROTEIN |
| Protein Type | Transferase |
| Function | is an essential component of the oligosacchryltransferase (OST) complex located in the endoplasmic reticulum (ER) membrane. |
| Subcellular Localization | </strong></td><td>Endoplasmic reticulum membrane</td></tr> |
| Molecular Weight | 69 kDa |
| GeneCards | RPN2PROTEIN |
| Human Protein Atlas | RPN2PROTEIN |
| N-terminal luminal domain | Catalytic OST subunit interaction |
| Transmembrane domain | Single-pass membrane anchor |
| C-terminal domain | STT3A/STT3B binding |
| OST core | RPN1, RPN2, STT3A, STT3B, DAD1, OTF |
| Accessory subunits | MagT1, TUSC3, KCP2 |
| Ribosome interaction | Direct binding to Sec61 translocon |
| Calnexin/calreticulin cycle | Glycan-dependent folding |
| ER-associated degradation (ERAD) | Misfolded protein clearance |
| Associated Diseases | cancer |
| Interactions | ADRA2A, BCL-2, CANCER, CTSD, INFLAMMATION, MAOA |
| KG Connections | 22 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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