gene

CTSD

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CTSD: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1566Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

CTSD is a gene implicated in neurodegeneration research. Key relationships include: interacts with, associated with, regulates. Associated with AD, ADH, ALI. Connected to 651 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CTSD
Full Name	Cathepsin D
Aliases	CPSD, CLN10
Chromosome	11p15.5
Protein Type	Protease
Function	is a lysosomal aspartic protease encoded by the CTSD gene.
Primary Expression	Brain, liver, macrophages, neurons, microglia
Molecular Weight	48 kDa
Pathways	Akt, Angiogenesis, Apoptosis, Autophagy, Blood-Brain Barrier
UniProt ID	P07339
NCBI Gene ID	1509
Ensembl ID	ENSG00000103811
GeneCards	CTSD
Human Protein Atlas	CTSD
Associated Diseases	AD, ADH, ALI, ALS, AMI, Aging
Known Drugs/Compounds	RAPAMYCIN, COENZYME Q10, rapamycin, CHLOROQUINE
Interactions	RB1, EIF2AK3, PRKN, BCL2L11, MUL1, BNIP3
KG Connections	1566 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CTSD — AlphaFold P07339 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CTSD["CTSD"] -->|"activates"| Metabolic_Syndrome["Metabolic Syndrome"]
    CTSD["CTSD"] -->|"regulates"| Ischemia["Ischemia"]
    CTSD["CTSD"] -->|"regulates"| Ms["Ms"]
    CTSD["CTSD"] -->|"interacts"| Dementia["Dementia"]
    CTSD["CTSD"] -->|"interacts"| Cardiovascular["Cardiovascular"]
    CTSD["CTSD"] -->|"interacts"| Als["Als"]
    ACTB["ACTB"] -->|"regulates"| CTSD["CTSD"]
    PPARA["PPARA"] -->|"regulates"| CTSD["CTSD"]
    CAT["CAT"] -->|"regulates"| CTSD["CTSD"]
    SQSTM1["SQSTM1"] -->|"regulates"| CTSD["CTSD"]
    style CTSD fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (988)

Target	Relation	Type	Str
Amyloid fibril fragmentation	mediates	process	0.95
HSP90α	inhibits	protein	0.90
Lysosomal Function	regulates	process	0.90
Autophagy	involved_in	process	0.90
neural stem cells	activates	cell_type	0.90
Amyloid propagation	contributes_to	process	0.87
Alpha-Synuclein Neurotoxicity	modulates	phenotype	0.85
α-synuclein neurotoxicity	modulates	phenotype	0.80
Cell Proliferation	modulates	process	0.80
Parkinson's disease	contributes_to	disease	0.80
Apoptosis	modulates	process	0.80
neural stem cells	regulates	cell_type	0.80
Alzheimer	associated_with	disease	0.75
Als	associated_with	disease	0.75
Aging	associated_with	disease	0.75
Dementia	associated_with	disease	0.75
Neuroinflammation	involved_in	process	0.75
PPARGC1A	regulates	gene	0.70
osteoporosis	associated_with	disease	0.70
SQSTM1	regulates	gene	0.70
LPL	associated_with	gene	0.70
SNCA	regulates	protein	0.70
autophagy	regulates	process	0.70
SNCA aggregates	inhibits	protein	0.70
MCOLN1	activates	gene	0.70
MCOLN1	interacts_with	gene	0.70
ULK1	interacts_with	gene	0.70
atherosclerosis	associated_with	disease	0.70
Complement	associated_with	pathway	0.70
Autophagy	inhibits	pathway	0.70
Parkinson's disease	activates	disease	0.70
Alzheimer's disease	activates	disease	0.70
LC3B	regulates	gene	0.70
Parkinson's disease	regulates	disease	0.70
oxidative stress response	participates_in	pathway	0.70
GFP	activates	gene	0.70
GFP	interacts_with	gene	0.70
Alzheimer's disease	interacts_with	disease	0.70
Retinal Degeneration	activates	disease	0.65
LAMP2	phosphorylates	gene	0.65
PARP1	co_discussed	gene	0.65
TNF	co_discussed	gene	0.65
endosome	co_discussed	concept	0.65
LRRK2	co_discussed	gene	0.65
TREM2	co_discussed	gene	0.65
TDP-43	activates	protein	0.65
Metabolic Syndrome	activates	disease	0.65
Ischemia	regulates	disease	0.65
Ms	regulates	disease	0.65
Dementia	interacts_with	disease	0.65

Incoming (578)

Source	Relation	Type	Str
lnc-HIBADH-4	regulates	biomarker	0.85
SLAMF7	inhibits	gene	0.80
LRP6	interacts_with	protein	0.80
LRP6	activates	protein	0.80
ATG	activates	gene	0.80
rapamycin	targets	drug	0.80
TNF	associated_with	gene	0.70
BCL2	regulates	gene	0.70
BECN1	regulates	gene	0.70
APOE	inhibits	gene	0.70
AMBRA1	regulates	gene	0.70
CTSB	interacts_with	gene	0.70
GENES	associated_with	gene	0.70
PRESENILIN	associated_with	gene	0.70
ATP	activates	gene	0.70
AMPK	regulates	gene	0.70
APOE	co_discussed	gene	0.65
BDNF	co_discussed	gene	0.65
CLU	co_discussed	gene	0.65
CR1	co_discussed	gene	0.65
TFEB	mediates	gene	0.65
MTOR	phosphorylates	gene	0.65
CHLOROQUINE	activates	drug	0.65
CANCER	targets	disease	0.65
MICROGLIA	regulates	cell_type	0.65
CERAMIDE	regulates	phenotype	0.65
ACTB	regulates	gene	0.60
PPARA	regulates	gene	0.60
CAT	regulates	gene	0.60
SQSTM1	regulates	gene	0.60
RPS6KB1	regulates	gene	0.60
RAB7A	regulates	gene	0.60
SREBF1	regulates	gene	0.60
EIF4EBP1	regulates	gene	0.60
CAT	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
DNM1L	interacts_with	gene	0.60
CANX	interacts_with	gene	0.60
LGALS3	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
PEX3	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
BCL2	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
TAX1BP1	interacts_with	gene	0.60
ATM	interacts_with	gene	0.60
SNCAIP	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Tau propagation mechanisms and therapeutic interception points

neurodegeneration | 2026-04-03 | 1 hypotheses Top: 0.512

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CTSD

Understanding Entity Pages

Summary

Wiki Pages (21)

CTSD — Cathepsin D

Progressive Supranuclear Palsy (PSP)

Multiple System Atrophy

Alzheimer's Disease

TREM2 Mechanism Hub

Neuronal Ceroid Lipofuscinosis (NCL)

Autophagy-Lysosomal Impairment Comparison — AD/PD/ALS/FTD/HD

Lysosomal Dysfunction in Neurodegeneration

Microglia Activation Mechanism

autophagy-lysosome-dysfunction

Protein Quality Control in Neurodegeneration

CBS Microglial Neuroimmune Axis

Lysosomal Storage Diseases

CTSD Gene - Cathepsin D

tfeb-activators-neurodegeneration

Microglial Proteins in CSF Reveal AD Progression States

CTSD — Cathepsin D

TREM2-SYK Signaling Cascade

Endosomal-Lysosomal Pathway in Neurodegeneration

TFEB Autophagy Pathway