gene

CTSD

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CTSD: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1555Connections

1Hypotheses

6Analyses

50Outgoing

50Incoming

0Experiments

15Debates

Summary

CTSD is a gene implicated in neurodegeneration research. Key relationships include: interacts with, associated with, regulates. Associated with AD, ADH, ALI. Connected to 651 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CTSD
Full Name	Cathepsin D
Aliases	CPSD, CLN10
Chromosome	11p15.5
Protein Type	Protease
Function	is a lysosomal aspartic protease encoded by the CTSD gene.
Primary Expression	Brain, liver, macrophages, neurons, microglia
Molecular Weight	48 kDa
Pathways	Akt, Angiogenesis, Apoptosis, Autophagy, Blood-Brain Barrier
UniProt ID	P07339
NCBI Gene ID	1509
Ensembl ID	ENSG00000103811
GeneCards	CTSD
Human Protein Atlas	CTSD
Pre-proenzyme	Signal peptide + prosegment + mature enzyme
Associated Diseases	AD, ADH, Aging, ALI, Als
Known Drugs/Compounds	CHLOROQUINE, COENZYME Q10, H2S, rapamycin, RAPAMYCIN
Interactions	ABCA1, ABCD3, ACTB, Actin, ADRA2A, AGING
SciDEX Hypotheses	Cathepsin D Enhancement for Tau Degradation
KG Connections	1554 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CTSD — AlphaFold P07339 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CTSD["CTSD"] -->|"activates"| Metabolic_Syndrome["Metabolic Syndrome"]
    CTSD["CTSD"] -->|"regulates"| Ischemia["Ischemia"]
    CTSD["CTSD"] -->|"regulates"| Ms["Ms"]
    CTSD["CTSD"] -->|"interacts"| Dementia["Dementia"]
    CTSD["CTSD"] -->|"interacts"| Cardiovascular["Cardiovascular"]
    CTSD["CTSD"] -->|"interacts"| Als["Als"]
    ACTB["ACTB"] -->|"regulates"| CTSD["CTSD"]
    PPARA["PPARA"] -->|"regulates"| CTSD["CTSD"]
    CAT["CAT"] -->|"regulates"| CTSD["CTSD"]
    SQSTM1["SQSTM1"] -->|"regulates"| CTSD["CTSD"]
    style CTSD fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (989)

Target	Relation	Type	Str
CTSD	encodes	protein	0.00
Amyloid fibril fragmentation	mediates	process	0.95
HSP90α	inhibits	protein	0.90
CLN10	associated_with	disease	0.90
Neuronal ceroid lipofuscinosis	causes	disease	0.90
CLN10	causes	disease	0.90
neural stem cells	activates	cell_type	0.90
Lysosomal Function	regulates	process	0.90
Autophagy	associated_with	process	0.90
neuronal ceroid lipofuscinosis	causes	disease	0.90
Amyloid propagation	contributes_to	process	0.87
lysosomal_degradation	catalyzes	pathway	0.85
Alpha-Synuclein Neurotoxicity	modulates	phenotype	0.85
neuronal ceroid lipofuscinosis	associated_with	disease	0.80
Parkinson's disease	contributes_to	disease	0.80
lysosomal-autophagy machinery	part_of	pathway	0.80
neural stem cells	regulates	cell_type	0.80
Apoptosis	modulates	process	0.80
α-synuclein neurotoxicity	modulates	phenotype	0.80
Cell Proliferation	modulates	process	0.80
autophagy	part_of	pathway	0.80
proteostasis	modulates	pathway	0.80
lysosome	part_of	cell_type	0.80
Dementia	associated_with	disease	0.75
Aging	associated_with	disease	0.75
Neuroinflammation	involved_in	process	0.75
Alzheimer	associated_with	disease	0.75
Als	associated_with	disease	0.75
endocytosis	part_of	pathway	0.70
Complement	associated_with	pathway	0.70
phagocytosis	part_of	pathway	0.70
atherosclerosis	associated_with	disease	0.70
SNCA	targets	protein	0.70
Parkinson disease	associated_with	disease	0.70
protein aggregates	disrupts	compound	0.70
Parkinson's disease	regulates	disease	0.70
GFP	activates	gene	0.70
Alzheimer's disease	activates	disease	0.70
MCOLN1	interacts_with	gene	0.70
MCOLN1	activates	gene	0.70
ULK1	interacts_with	gene	0.70
Parkinson's disease	activates	disease	0.70
LC3B	regulates	gene	0.70
oxidative stress response	participates_in	pathway	0.70
GFP	interacts_with	gene	0.70
SNCA	regulates	protein	0.70
SQSTM1	regulates	gene	0.70
autophagy	regulates	process	0.70
osteoporosis	associated_with	disease	0.70
PPARGC1A	regulates	gene	0.70

Incoming (566)

Source	Relation	Type	Str
CTSD	encodes	gene	0.00
lnc-HIBADH-4	regulates	biomarker	0.85
LRP6	interacts_with	protein	0.80
SLAMF7	inhibits	gene	0.80
ATG	activates	gene	0.80
LRP6	activates	protein	0.80
rapamycin	targets	drug	0.80
APOE	inhibits	gene	0.70
ATP	activates	gene	0.70
GENES	associated_with	gene	0.70
PRESENILIN	associated_with	gene	0.70
AMBRA1	regulates	gene	0.70
BCL2	regulates	gene	0.70
AMPK	regulates	gene	0.70
CTSB	interacts_with	gene	0.70
TNF	associated_with	gene	0.70
BECN1	regulates	gene	0.70
BDNF	co_discussed	gene	0.65
CHLOROQUINE	activates	drug	0.65
MICROGLIA	regulates	cell_type	0.65
MTOR	phosphorylates	gene	0.65
CERAMIDE	regulates	phenotype	0.65
CANCER	targets	disease	0.65
APOE	co_discussed	gene	0.65
CLU	co_discussed	gene	0.65
CR1	co_discussed	gene	0.65
TFEB	mediates	gene	0.65
EPAS1	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
PEX3	interacts_with	gene	0.60
FAM134B	interacts_with	gene	0.60
SNCA	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
SREBF1	regulates	gene	0.60
FMR1	interacts_with	gene	0.60
PARKIN	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
MFN1	interacts_with	gene	0.60
LGALS3	interacts_with	gene	0.60
RAB7A	regulates	gene	0.60
CAT	regulates	gene	0.60
GLA	associated_with	gene	0.60
BCL2L1	associated_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
RAB9A	associated_with	gene	0.60
GABARAP	associated_with	gene	0.60
PSEN2	associated_with	gene	0.60
DDIT3	interacts_with	gene	0.60
BCL2	associated_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Cathepsin D Enhancement for Tau Degradation	0.000	-	Tau propagation mechanisms and therapeut

Mentioning Analyses (6)

Scientific analyses that reference this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (15)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning CTSD in their description or question text

No additional research found

CTSD

Understanding Entity Pages

Summary

Wiki Pages (7)

CTSD — Cathepsin D

CTSD Gene - Cathepsin D

CTSD — Cathepsin D

CTSD (Cathepsin D)

Cathepsin D (CTSD)

CTSD Protein - Cathepsin D

Pathway Diagram

Outgoing (989)

Incoming (566)

Targeting Hypotheses (1)

Mentioning Analyses (6)

Why have anti-Aβ clinical trials failed despite the established role of Aβ in AD

Neuroinflammation and microglial priming in early AD

Tau propagation mechanisms and therapeutic interception points

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

Experiments (0)

Related Papers (0)

Debates (15)

Second debate: Microglial TREM2-SYK Pathway Enhancement

Debate: LPCAT3-Mediated Lands Cycle Remodeling as the Primary Ferroptotic Primin

Debate: ALOX15-Driven Enzymatic Ferroptosis in AD Oligodendrocytes via PUFA-PE P

Debate: LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Vulnerability i

Debate: ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligodendrocytes

Should '40 Hz Gamma Entrainment Gates ACSL4-Mediated Ferroptotic Priming to Sele

Should 'ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drives White Matt

The abstract suggests that Aβ-tau synergy could explain negative results from an

Investigate prion-like spreading of tau pathology through connected brain region

How does microglial priming contribute to early Alzheimer's disease pathology? F

Related Research