| Gene Symbol | RYR1 |
| Chromosome | 19q13.1 |
| Protein Family | Ryanodine receptor family |
| Protein Type | Channel |
| Function | RYR1 is a large calcium release channel on the sarcoplasmic reticulum in skeletal muscle. |
| Primary Expression | various brain regions including the hippocampus and cerebellum, where it contributes to synaptic plasticity, dendritic s |
| Molecular Weight | 564 kDa |
| Amino Acids | 038 aa |
| UniProt ID | P21817 |
| GeneCards | RYR1 |
| Human Protein Atlas | RYR1 |
| RYR2/RYR3 | Cardiac and neuronal ryanodine receptor isoforms with distinct tissue distributions |
| DHPR (Cav1.1) | L-type calcium channel mediating mechanical coupling to RYR1 |
| FKBP12 | Regulatory protein stabilizing RYR1 channel gating |
| Mitochondrial Calcium Uniporter | Transporter mediating ER-to-mitochondrial calcium transfer |
| Associated Diseases | Cardiac |
| KG Connections | 5 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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