| Gene Symbol | RYR2 |
| Full Name | Ryanodine Receptor 2 |
| Aliases | Page for RYR2 |
| Protein Family | Ryanodine receptor family |
| Protein Type | Channel |
| Function | RYR2 is the cardiac ryanodine receptor, essential for calcium-induced calcium release in heart muscle. |
| Primary Expression | various neuronal populations including hippocampal neurons and cerebellar granule cells, where it contributes to synaptic plastic |
| Molecular Weight | 565 kDa |
| Amino Acids | 647 aa |
| Exons | 105 |
| Pathways | Apoptosis, Nf-Κb, Oxidative Phosphorylation |
| UniProt ID | Q92736 |
| GeneCards | RYR2 |
| Human Protein Atlas | RYR2 |
| FKBP12.6 (calstabin-2) | Stabilizes the closed state of RYR2 |
| Associated Diseases | ALS, Aging, Cancer, Cardiac, Heart Failure |
| Interactions | RAC1, LMNA, VEGFA, EXERCISE, NEUROINFLAMMATION, EPILEPSY |
| KG Connections | 99 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |