gene 729 words KG: CAT 2026-03-17
kind:genesection:genesstate:published
Contents

CAT — Catalase

🧬 Gene Info
Gene SymbolCAT
Full NameCatalase
Chromosome11
Protein TypeEnzyme
FunctionCatalase is a tetrameric heme-containing enzyme that functions as one of the primary antioxidant defenses in cells.
Primary Expressionperoxisomes (primary location), cytosol and mitochondria, with highest levels in liver, kidney, and brain
Subcellular Localization**: Peroxisomes
PathwaysAkt, Apoptosis, Autophagy, Epigenetic, Ferroptosis
UniProt IDP04040
NCBI Gene ID847
Ensembl IDENSG00000121691
OMIM115500
GeneCardsCAT
Human Protein AtlasCAT
Associated DiseasesAD, ADH, ALI, ALS, AMI, Aging
Known Drugs/Compoundsrapamycin
InteractionsOPTN, DNM1L, CANX, LGALS3, CALCOCO2, G3BP1
KG Connections1394 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (20)

Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.50
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.38
Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68

Related Analyses (8)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Cell type vulnerability in Alzheimer's Disease (SEA-AD data
neurodegeneration · archived
Cell type vulnerability in Alzheimers Disease (SEA-AD transc
neurodegeneration · archived
Cell type vulnerability in Alzheimers Disease (SEA-AD transc
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived

Related Experiments (4)

Epigenetic Dysregulation Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
Microglial Aging and Immune Memory in Neurodegeneration — Tr
validation · proposed · Score: 0.40
Multiscale Computational Modeling of Protein Aggregation Kin
validation · proposed · Score: 0.40
Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40

See Also (15)

Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed
Packard Center for ALS Research
institution · KG edge: activates
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
Alzheimer Indonesia
institution · KG edge: activates
ALOX15 - Arachidonate 15-Lipoxygenase
gene · KG edge: debate_co_mention

Knowledge Graph (12 edges)

CAT activates CTSD
CAT activates EGFR
CAT activates EIF4EBP1
CAT activates LAMP1
CAT activates LRP2
CAT activates MAP1LC3B
CAT activates MYC
CAT activates PIK3C3
CAT activates PPARA
CAT activates PPARG