| Gene Symbol | SHANK3 |
| Full Name | SH3 and Multiple Ankyrin Repeat Domains 3 |
| Aliases | Page for SHANK3, Page for SHANK3 Protein |
| Chromosome | 22q13.33. |
| Function | Postsynaptic density assembly: Recruits and organizes synaptic proteins |
| Subcellular Localization | </strong></td><td>Postsynaptic density, dendritic spines</td></tr> |
| Molecular Weight | 180 kDa |
| Amino Acids | 620 aa |
| UniProt ID | [Q9BYB0](https://www.uniprot.org/uniprot/Q9BYB0) |
| Ensembl ID | ENSG00000132924 |
| GeneCards | SHANK3 |
| Human Protein Atlas | SHANK3 |
| Isoform a | Full-length, brain-specific |
| Isoform b | Missing ANK repeats 2-3 |
| Isoform c | Alternative C-terminus |
| Associated Diseases | Als |
| Interactions | ACC, ANK3, CACNA1G, GENES, KCNH7, KMT2A |
| KG Connections | 47 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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