Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about KCNH7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
KCNH7: Voltage-gated potassium channel (ERG3) regulating neuronal excitability, pacemaker activity, and implicated in neurodegenerative diseases through ion channel dysfunction
| Gene Symbol | KCNH7 |
| Chromosome | 2q31.1 |
| Function | is a member of the ether-à-go-go family of voltage-gated potassium channels. |
| Primary Expression | CNS predominant |
| Molecular Weight | ~110 kDa |
| Amino Acids | 964 aa |
| Exons | 15 |
| UniProt ID | Q9NS88 |
| NCBI Gene ID | 343472 |
| Ensembl ID | ENSG00000168619 |
| GeneCards | KCNH7 |
| Human Protein Atlas | KCNH7 |
| Alternative Names | ERG3, Ether-à-go-go-related protein 3 |
| GRCh38 Coordinates | chr2:164,287,428-164,772,628 |
| Protein Length | 964 amino acids |
| Associated Diseases | Alzheimer's disease, Parkinson's disease, Epilepsy |
| Interactions | SST, AND, NEURON, ACC, Albumin, SHANK3 |
| KG Connections | 28 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
KCNH7["<b>KCNH7</b>"]
Als{"Als"}
KCNH7 -->|"therapeutic target"| Als
Tumor{"Tumor"}
KCNH7 -->|"therapeutic target"| Tumor
Glioblastoma{"Glioblastoma"}
KCNH7 -->|"therapeutic target"| Glioblastoma
GBM["GBM"]
KCNH7 -->|"associated with"| GBM
DIAPH3["DIAPH3"]
KCNH7 -->|"associated with"| DIAPH3
SYT1["SYT1"]
KCNH7 -->|"associated with"| SYT1
neurodegeneration["neurodegeneration"]
KCNH7 -->|"implicated in"| neurodegeneration
style KCNH7 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Als | therapeutic_target | disease | 0.65 |
| Tumor | therapeutic_target | disease | 0.65 |
| Glioblastoma | therapeutic_target | disease | 0.65 |
| Autism | inhibits | disease | 0.65 |
| GBM | associated_with | gene | 0.60 |
| DIAPH3 | associated_with | gene | 0.60 |
| SYT1 | associated_with | gene | 0.60 |
| Pyramidal | interacts_with | cell_type | 0.60 |
| SST | inhibits | gene | 0.60 |
| Interneuron | inhibits | cell_type | 0.60 |
| Neuron | inhibits | cell_type | 0.60 |
| AND | inhibits | gene | 0.60 |
| NEURON | inhibits | gene | 0.60 |
| ACC | interacts_with | gene | 0.60 |
| Albumin | interacts_with | protein | 0.60 |
| Cortex | expressed_in | brain_region | 0.55 |
| Hippocampus | expressed_in | brain_region | 0.55 |
| Interneuron | expressed_in | cell_type | 0.55 |
| Neuron | expressed_in | cell_type | 0.55 |
| INTERNEURON | inhibits | concept | 0.50 |
| INTERNEURONS | inhibits | concept | 0.50 |
| Neuron | interacts_with | cell_type | 0.50 |
| INTERNEURON | interacts_with | concept | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||