protein 1,169 words KG: SYNAPSIN1PROTEIN
Contents

Synapsin-1 Protein

🔬 Protein Info
Gene SymbolSYNAPSIN1
Full NameSYN1 — Synapsin I
AliasesSynapsin I
Protein TypeGene
FunctionSynapsin I is a neuronal phosphoprotein associated with the cytoplasmic surface of synaptic vesicles
Primary Expressionneurons and is involved in anchoring synaptic vesicles to the cytoskeleton, maintaining the reserve pool of vesicles, and regulat
Subcellular Localization</strong></td><td>Presynaptic terminal (synaptic vesicles)</td></tr>
Molecular Weight70 kDa
Amino Acids706 aa
GeneCardsSYNAPSIN1
Human Protein AtlasSYNAPSIN1
Vesicle recruitmentPhosphorylated synapsin mobilizes vesicles from the reserve pool to the readily releasable pool
Release probabilitySynapsin-1 deletion reduces the size of the readily releasable pool
Recovery after releaseSynapsin-1 helps recycle vesicles back into the cluster
Spontaneous releaseSynapsin-1 also regulates spontaneous (action potential-independent) release
Associated DiseasesEpilepsy
InteractionsDEPDC5, NEURON
KG Connections13 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

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Related Hypotheses (11)

APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.71
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Axonal RNA Transport Reconstitution
Score: 0.70
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Pharmacological Enhancement of APOE4 Glycosylation
Score: 0.62
Lysosomal Membrane Repair Enhancement
Score: 0.54
Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioener
Score: 0.53
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (10)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived

See Also (15)

Exosomal Biomarkers in Neurodegeneration
biomarker · Pages share 9 hypotheses
Exosomal miR-155 in Neurodegeneration
biomarker · Pages share 9 hypotheses
IL-6 (Interleukin-6) in Neurodegeneration
biomarker · Pages share 9 hypotheses
Liquid Biopsy in Neurodegeneration
biomarker · Pages share 9 hypotheses
Metabolomic Biomarkers in Neurodegeneration
biomarker · Pages share 9 hypotheses

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